Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

As the most common chronic degenerative joint disease, osteoarthritis (OA) is the leading
cause of pain and physical disability, affecting millions of people worldwide. Mainly …

Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …

The increase in global lifespan has in turn increased the prevalence of osteoarthritis which
is now the most common type of arthritis. Cartilage tissue located on articular joints erodes …

Our incomplete understanding of osteoarthritis (OA) pathogenesis has significantly hindered
the development of disease-modifying therapy. The functional relationship between …

Cartilage homeostasis is governed by articular chondrocytes via their ability to modulate
extracellular matrix production and degradation. In turn, chondrocyte activity is regulated by …

Osteoarthritis (OA) is a degenerative joint disorder commonly encountered in clinical
practice, and is the leading cause of disability in elderly people. Due to the poor self-healing …

Mechanical stress plays a critical role in cartilage development and homoeostasis.
Chondrocytes are surrounded by a narrow pericellular matrix (PCM), which absorbs …

Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with
age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal …