Importance Septic shock currently refers to a state of acute circulatory failure associated with
infection. Emerging biological insights and reported variation in epidemiology challenge the …

Objective: The aim of this study was to describe current understanding of the local and
systemic immune responses to surgery and their impact on clinical outcomes, predictive …

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Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Objectives: To prospectively validate that the inability to decrease procalcitonin levels by
more than 80% between baseline and day 4 is associated with increased 28-day all-cause …

Rationale: Tools that screen inpatients for sepsis use the systemic inflammatory response
syndrome (SIRS) criteria and organ dysfunctions, but most studies of these criteria were …

Background A proposed revision of sepsis definitions has abandoned the systemic
inflammatory response syndrome (SIRS), defined organ dysfunction as an increase in total …

Background New sepsis and septic shock definitions could change the epidemiology of
sepsis because of differences in criteria. We therefore compared the sepsis populations …

Objective: To test whether the association between initial serum lactate level and mortality in
patients presenting to the emergency department (ED) with severe sepsis is independent of …

Objectives: Organ failure worsens outcome in sepsis. The Sequential Organ Failure
Assessment (SOFA) score numerically quantifies the number and severity of failed organs …