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Concept of hybrid drugs and recent advancements in anticancer hybrids
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships
Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …
resistance associated with the currently used anticancer agents create an urgent need to …
Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy
M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …
Recent advances (2015–2016) in anticancer hybrids
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …
Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains
Microtubules are a protein which is made of α-and β-heterodimer. It is one of the main
components of the cell which play a vital role in cell division especially in G2/M-phase. It …
components of the cell which play a vital role in cell division especially in G2/M-phase. It …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
1, 2, 3-Triazole-containing compounds as anti–lung cancer agents: Current developments, mechanisms of action, and structure–activity relationship
T Liang, X Sun, W Li, G Hou, F Gao - Frontiers in pharmacology, 2021 - frontiersin.org
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …
deaths. Great advances have been achieved in the treatment of lung cancer with novel …
Curcumin analogues and their hybrid molecules as multifunctional drugs
Abstract Curcumin (diferuloylmethane or 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …
Developments in the anticancer activity of structurally modified curcumin: An up-to-date review
Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …
[HTML][HTML] A mini review on isatin, an anticancer scaffold with potential activities against Neglected Tropical Diseases (Ntds)
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …
therapeutic fragments in drug design and development. The template has turned out to be …