Concept of hybrid drugs and recent advancements in anticancer hybrids

AK Singh, A Kumar, H Singh, P Sonawane, H Paliwal… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

1, 2, 3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships

Z Xu, SJ Zhao, Y Liu - European journal of medicinal chemistry, 2019 - Elsevier
Anticancer agents are critical for the cancer treatment, but side effects and the drug
resistance associated with the currently used anticancer agents create an urgent need to …

Recent advances of tubulin inhibitors targeting the colchicine binding site for cancer therapy

M Hawash - Biomolecules, 2022 - mdpi.com
Cancer accounts for numerous deaths each year, and it is one of the most common causes
of death worldwide, despite many breakthroughs in the discovery of novel anticancer …

Recent advances (2015–2016) in anticancer hybrids

N Kerru, P Singh, N Koorbanally, R Raj… - European journal of …, 2017 - Elsevier
In spite of the development of a large number of novel anticancer drugs over the years,
Cancer remains as a prominent cause of death, worldwide. Numerous drugs that are …

Anti-tubulin agents of natural origin: Targeting taxol, vinca, and colchicine binding domains

F Naaz, MR Haider, S Shafi, MS Yar - European journal of medicinal …, 2019 - Elsevier
Microtubules are a protein which is made of α-and β-heterodimer. It is one of the main
components of the cell which play a vital role in cell division especially in G2/M-phase. It …

[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents

K Haider, M Shafeeque, S Yahya, MS Yar - European Journal of Medicinal …, 2022 - Elsevier
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

1, 2, 3-Triazole-containing compounds as anti–lung cancer agents: Current developments, mechanisms of action, and structure–activity relationship

T Liang, X Sun, W Li, G Hou, F Gao - Frontiers in pharmacology, 2021 - frontiersin.org
Lung cancer is the most common malignancy and leads to around one-quarter of all cancer
deaths. Great advances have been achieved in the treatment of lung cancer with novel …

Curcumin analogues and their hybrid molecules as multifunctional drugs

SA Noureddin, RM El-Shishtawy, KO Al-Footy - European journal of …, 2019 - Elsevier
Abstract Curcumin (diferuloylmethane or 1, 7-bis (4-hydroxy-3-methoxyphenyl)-1, 6-
heptadiene-3, 5-dione) is an interesting compound that is characterized by a special …

Developments in the anticancer activity of structurally modified curcumin: An up-to-date review

FC Rodrigues, NVA Kumar, G Thakur - European journal of medicinal …, 2019 - Elsevier
Curcumin is a pharmacologically active polyphenol derived from the popular spice element-
Turmeric. The therapeutic activity of curcumin has been extensively investigated over the …

[HTML][HTML] A mini review on isatin, an anticancer scaffold with potential activities against Neglected Tropical Diseases (Ntds)

S Chowdhary, Shalini, A Arora, V Kumar - Pharmaceuticals, 2022 - mdpi.com
Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …