Mitochondria as potential targets in Alzheimer disease therapy: an update

G Cenini, W Voos - Frontiers in pharmacology, 2019 - frontiersin.org
Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Exercise therapy to prevent and treat Alzheimer's disease

HA Pahlavani - Frontiers in Aging Neuroscience, 2023 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disease in the elderly with
dementia, memory loss, and severe cognitive impairment that imposes high medical costs …

Physical exercise and health: a focus on its protective role in neurodegenerative diseases

R Bonanni, I Cariati, U Tarantino… - Journal of functional …, 2022 - mdpi.com
Scientific evidence has demonstrated the power of physical exercise in the prevention and
treatment of numerous chronic and/or age-related diseases, such as musculoskeletal …

Central and peripheral metabolic defects contribute to the pathogenesis of Alzheimer's disease: targeting mitochondria for diagnosis and prevention

Y Peng, P Gao, L Shi, L Chen, J Liu… - Antioxidants & redox …, 2020 - liebertpub.com
Significance: Epidemiological studies indicate that metabolic disorders are associated with
an increased risk for Alzheimer's disease (AD). Metabolic remodeling occurs in the central …

Activation of Nrf2 signaling by sitagliptin and quercetin combination against β‐amyloid induced Alzheimer's disease in rats

Y Li, Q Tian, Z Li, M Dang, Y Lin… - Drug development …, 2019 - Wiley Online Library
The objective of this study was to evaluate the neuroprotective effect of sitagliptin (Sita),
quercetin (QCR) and its combination in β‐amyloid (Aβ) induced Alzheimer's disease (AD) …

[HTML][HTML] Exercise, redox system and neurodegenerative diseases

H Quan, E Koltai, K Suzuki, AS Aguiar Jr… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Regular exercise induces a wide range of redox system-associated molecular adaptive
responses to the nervous system. The intermittent induction of reactive oxygen species …

Mitochondrial mechanisms in Alzheimer's disease: Quest for therapeutics

K Kalani, P Chaturvedi, P Chaturvedi, VK Verma… - Drug Discovery …, 2023 - Elsevier
Highlights•Mitochondria decide the progression of Alzheimer's disease.•AD pathology and
severity are determined by mitochondrial dynamics and energetic mechanisms.•Mitophagy …

[HTML][HTML] Intensity-specific effects of acute exercise on human memory function: Considerations for the timing of exercise and the type of memory

PD Loprinzi - Health promotion perspectives, 2018 - ncbi.nlm.nih.gov
Background: The purpose of this review was to evaluate whether acute exercise intensities
have unique effects on memory function, and whether this is influenced by memory type as …

Environmental enrichment improves cognitive function, learning, memory and anxiety-related behaviours in rodent models of dementia: implications for future study

SNM Sahini, NAMN Hazalin, BN Srikumar… - … of Learning and …, 2024 - Elsevier
Environmental enrichment (EE) is a process of brain stimulation by modifying the
surroundings, for example, by changing the sensory, social, or physical conditions. Rodents …

Resveratrol supplementation attenuates cognitive and molecular alterations under maternal high-fat diet intake: epigenetic inheritance over generations

V Izquierdo, V Palomera-Ávalos, M Pallàs… - International journal of …, 2021 - mdpi.com
Environmental factors such as maternal high-fat diet (HFD) intake can increase the risk of
age-related cognitive decline in adult offspring. Epigenetic mechanisms are a possible link …