Peptide-based specific biosensors for bioanalysis of human health

X Qin, X Cai, J **ao - TrAC Trends in Analytical Chemistry, 2025 - Elsevier
The preservation of human health stands as crucial for both individual well-being and
societal stability. The major diseases and pathogenic infections that impact humans present …

The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer

W Tang, Y Yang, Z Fu, W Xu, W Ou, F Liu, P Du, CY Liu - Oncogene, 2024 - nature.com
The RNA helicase DDX21 is vital for ribosome biogenesis and is upregulated in CRC, but
the mechanism by which DDX21 is dysregulated and by which DDX21 promotes …

The disruptive role of LRG1 on the vasculature and perivascular microenvironment

A Dritsoula, C Camilli, SE Moss… - Frontiers in …, 2024 - frontiersin.org
The establishment of new blood vessels, and their subsequent stabilization, is a critical
process that facilitates tissue growth and organ development. Once established, vessels …

YAP/TEAD4/SP1-induced VISTA expression as a tumor cell-intrinsic mechanism of immunosuppression in colorectal cancer

Z Zhu, R Ding, W Yu, Y Liu, Z Zhou… - Cell Death & Differentiation, 2025 - nature.com
Hyperactivation of the YAP/TEAD transcriptional complex in cancers facilitates the
development of an immunosuppressive tumor microenvironment. Herein, we observed that …

The regulatory role of tRNA-derived small RNAs in the prognosis of gastric cancer

X Shen, S Xu, Z Zheng, W Liang, J Guo - Cellular Signalling, 2025 - Elsevier
In recent years, tRNA-derived small RNAs (tsRNAs) including tRNA-derived stress-induced
RNAs (tiRNAs) and tRNA-derived fragments (tRFs), with specific structure and enriched in …

[HTML][HTML] Graphene-based synthetic peptide electrochemical sensor for colorectal cancer diagnosis

M Yu, Q Li, H Yu - Alexandria Engineering Journal, 2024 - Elsevier
This work reports the development of an electrochemical sensor using graphene-peptide
conjugates for detecting colorectal cancer (CRC) biomarker leucine-rich alpha-2 …

LncRNA SNHG16 Drives PD-L1-Mediated Immune Escape in Colorectal Cancer through Regulating miR-324-3p/ELK4 Signaling

Z Chen, Z Wu, M Wu, Y Zhang, S Hou, X Wang… - Biochemical …, 2024 - Springer
Colorectal cancer (CRC) is a common malignancy that claims the life of many patients.
Nucleolar RNA host gene 16 (SNHG16) has been identified as an oncogene in CRC …

CircNUP98 promotes the malignant behavior of glioma cells through the miR‐520f‐3p/ELK4 axis

L Nie, T Jiang - International Journal of Developmental …, 2024 - Wiley Online Library
Glioma, a formidable form of brain cancer, poses significant challenges in terms of treatment
and prognosis. Circular RNA nucleoporin 98 (circNUP98) has emerged as a potential …

Plasma Leucine-Rich Alpha-2-Glycoprotein 1 Reflects Higher Histological Grade, Worse Disease-Free Survival, and Unfavorable Overall Survival in Colorectal …

Z Tan, W Wang, J Peng, W Fan, H Cao - The Tohoku Journal of …, 2024 - jstage.jst.go.jp
Abstract Leucine-rich alpha-2-glycoprotein 1 (LRG1) promotes colorectal cancer (CRC)
growth, migration, and invasion. This study intended to investigate the association of plasma …

ELK4 targets CHMP6 to inhibit ferroptosis and enhance malignant properties of skin cutaneous melanoma cells

H Li, Z Chen, Y Huang, C Chen, L Cai - Archives of Dermatological …, 2024 - Springer
Ferroptosis, a key factor in tumor progression, is poorly understood at the molecular level.
This study investigates how ELK4 and CHMP6 regulate skin cutaneous melanoma (SKCM) …