Oligonucleotide therapy: An emerging focus area for drug delivery in chronic inflammatory respiratory diseases

M Mehta, D Tewari, G Gupta, R Awasthi, H Singh… - Chemico-biological …, 2019 - Elsevier
Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary Disease …

Local cancer recurrence: the realities, challenges, and opportunities for new therapies

DA Mahvi, R Liu, MW Grinstaff… - CA: a cancer journal …, 2018 - Wiley Online Library
Locoregional recurrence negatively impacts both long‐term survival and quality of life for
several malignancies. For appropriate‐risk patients with an isolated, resectable, local …

The potential of siRNA based drug delivery in respiratory disorders: Recent advances and progress

K Dua, R Wadhwa, G Singhvi, V Rapalli… - Drug development …, 2019 - Wiley Online Library
Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti …

Surface-engineered dendrimers in gene delivery

J Yang, Q Zhang, H Chang, Y Cheng - Chemical reviews, 2015 - ACS Publications
1. DENDRIMERS AND GENE DELIVERY Gene therapy represents a promising option for
the treatment of diseases such as inherited disorders, viral infections, and cancers. 1− 3 A …

Dendrimers as nanoscale vectors: Unlocking the bars of cancer therapy

AD Dey, A Bigham, Y Esmaeili, M Ashrafizadeh… - Seminars in Cancer …, 2022 - Elsevier
Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …

[HTML][HTML] PAMAM dendrimer-cell membrane interactions

LJ Fox, RM Richardson, WH Briscoe - Advances in colloid and interface …, 2018 - Elsevier
PAMAM dendrimers have been conjectured for a wide range of biomedical applications due
to their tuneable physicochemical properties. However, their application has been hindered …

Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery

H Wang, L Qin, X Zhang, J Guan, S Mao - Journal of Controlled Release, 2022 - Elsevier
With the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world
has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have …

Nanotechnology-assisted metered-dose inhalers (MDIs) for high-performance pulmonary drug delivery applications

R Kumar, P Mehta, KR Shankar, MAK Rajora… - Pharmaceutical …, 2022 - Springer
Purpose Respiratory disorders pose a major threat to the morbidity and mortality to public
health. Here we reviewed the nanotechnology based pulmonary drug delivery using …

Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities

S Mangal, W Gao, T Li, QT Zhou - Acta pharmacologica sinica, 2017 - nature.com
Lung cancer is the second most prevalent and the deadliest among all cancer types.
Chemotherapy is recommended for lung cancers to control tumor growth and to prolong …

Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery

AM Shen, T Minko - Journal of Controlled Release, 2020 - Elsevier
Pulmonary delivery of lipid-based nanotherapeutics by inhalation presents an
advantageous alternative to oral and intravenous routes of administration that avoids …