The secretion profile of mesenchymal stem cells and potential applications in treating human diseases

Y Han, J Yang, J Fang, Y Zhou, E Candi… - … and Targeted Therapy, 2022 - nature.com
Mesenchymal stromal/stem cells (MSCs) possess multi-lineage differentiation and self-
renewal potentials. MSCs-based therapies have been widely utilized for the treatment of …

A brief overview of global trends in MSC-based cell therapy

D Jovic, Y Yu, D Wang, K Wang, H Li, F Xu… - Stem cell reviews and …, 2022 - Springer
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …

Clinical trials based on mesenchymal stromal cells are exponentially increasing: where are we in recent years?

U Galderisi, G Peluso, G Di Bernardo - Stem cell reviews and reports, 2022 - Springer
Mesenchymal stromal cells (MSCs), present in the stromal component of several tissues,
include multipotent stem cells, progenitors, and differentiated cells. MSCs have quickly …

Safety, tolerability, and activity of mesenchymal stem cells versus placebo in multiple sclerosis (MESEMS): a phase 2, randomised, double-blind crossover trial

A Uccelli, A Laroni, R Ali, MA Battaglia… - The Lancet …, 2021 - thelancet.com
Summary Background Mesenchymal stem cells (MSCs), also known as mesenchymal
stromal cells, have been proposed as a promising therapeutic option for people with multiple …

Shining the light on clinical application of mesenchymal stem cell therapy in autoimmune diseases

SA Jasim, AV Yumashev, WK Abdelbasset… - Stem Cell Research & …, 2022 - Springer
The autoimmune diseases are associated with the host immune system, chronic
inflammation, and immune reaction against self-antigens, which leads to the injury and …

[HTML][HTML] Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles

V Pulido-Escribano, B Torrecillas-Baena… - World Journal of Stem …, 2022 - ncbi.nlm.nih.gov
The use of mesenchymal stem-cells (MSC) in cell therapy has received considerable
attention because of their properties. These properties include high expansion and …

Advances and clinical challenges of mesenchymal stem cell therapy

R Mei, Z Wan, C Yang, X Shen, R Wang… - Frontiers in …, 2024 - frontiersin.org
In recent years, cell therapy has provided desirable properties for promising new drugs.
Mesenchymal stem cells are promising candidates for develo** genetic engineering and …

Pretreated mesenchymal stem cells and their secretome: enhanced immunotherapeutic strategies

Y Su, C Xu, W Cheng, Y Zhao, L Sui… - International journal of …, 2023 - mdpi.com
Mesenchymal stem cells (MSCs) with self-renewing, multilineage differentiation and
immunomodulatory properties, have been extensively studied in the field of regenerative …

Efficacy and Safety of Mesenchymal Stem Cell Transplantation in the Treatment of Autoimmune Diseases (Rheumatoid Arthritis, Systemic Lupus Erythematosus …

L Zeng, G Yu, K Yang, W **ang, J Li… - Stem cells …, 2022 - Wiley Online Library
Objective. To evaluate the efficacy and safety of mesenchymal stem cell (MSC)
transplantation in the treatment of autoimmune diseases. Methods. The Chinese and …

[HTML][HTML] Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access

L Giovannelli, E Bari, C Jommi, F Tartara, D Armocida… - Bioactive Materials, 2023 - Elsevier
Neurodegenerative diseases represent a growing burden on healthcare systems worldwide.
Mesenchymal stem cells (MSCs) have shown promise as a potential therapy due to their …