Acute myocardial infarction (AMI) and the heart failure that often follows, are major causes of
death and disability worldwide. As such, new therapies are required to limit myocardial …

Messenger RNA based therapeutics have the potential to cause a big revolution in medicine
as they can facilitate personalized medicines and allow patients to produce their own …

Increasing evidence has pointed to the important function of T cells in controlling immune
homeostasis and pathogenesis after myocardial infarction (MI), although the underlying …

Introduction: New treatments are required to improve clinical outcomes in patients with acute
myocardial infarction (AMI), for reduction of myocardial infarct (MI) size and preventing heart …

The heart is imbued with a vast lymphatic network that is responsible for fluid homeostasis
and immune cell trafficking. Disturbances in the forces that regulate microvascular fluid …

Pancreatic-type ribonucleases (ptRNases) are a large family of vertebrate-specific secretory
endoribonucleases. These enzymes catalyze the degradation of many RNA substrates and …

Upon vascular injury, tissue damage, ischemia, or microbial infection, intracellular material
such as nucleic acids and histones is liberated and comes into contact with the vessel wall …

Septic cardiomyopathy is a life-threatening organ dysfunction caused by sepsis.
Ribonuclease 1 (RNase 1) belongs to a group of host-defense peptides that specifically …

Despite substantial declines in mortality following myocardial infarction (MI), subsequent left
ventricular remodeling (LVRm) remains a significant long-term complication. Extracellular …

Abstract Purpose of Review Inflammation plays a key role in clearing cellular debris and
recovery after acute myocardial infarction (AMI). Dysregulation of or prolonged inflammation …