Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation

NA Trayanova, A Lyon, J Shade… - Physiological …, 2024‏ - journals.physiology.org
The complexity of cardiac electrophysiology, involving dynamic changes in numerous
components across multiple spatial (from ion channel to organ) and temporal (from …

Calcium in the pathophysiology of atrial fibrillation and heart failure

NC Denham, CM Pearman, JL Caldwell… - Frontiers in …, 2018‏ - frontiersin.org
Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship
exists between the two—AF exacerbates heart failure causing a significant increase in heart …

[HTML][HTML] Anatomically accurate high resolution modeling of human whole heart electromechanics: a strongly scalable algebraic multigrid solver method for nonlinear …

CM Augustin, A Neic, M Liebmann, AJ Prassl… - Journal of computational …, 2016‏ - Elsevier
Electromechanical (EM) models of the heart have been used successfully to study
fundamental mechanisms underlying a heart beat in health and disease. However, in all …

Three-dimensional cardiac computational modelling: methods, features and applications

A Lopez-Perez, R Sebastian, JM Ferrero - Biomedical engineering online, 2015‏ - Springer
The combination of computational models and biophysical simulations can help to interpret
an array of experimental data and contribute to the understanding, diagnosis and treatment …

Pro‐arrhythmogenic effects of atrial fibrillation‐induced electrical remodelling: insights from the three‐dimensional virtual human atria

MA Colman, OV Aslanidi, S Kharche… - The Journal of …, 2013‏ - Wiley Online Library
Key points• Previous studies have shown that atrial electrical properties are altered
(remodelled) by atrial fibrillation (AF) and that the recurrence of AF is high following …

Automated detection and classification of arrhythmia from ECG signals using feature-induced long short-term memory network

B Ganguly, A Ghosal, A Das, D Das… - IEEE Sensors …, 2020‏ - ieeexplore.ieee.org
This letter proposes an automated detection and classification of arrhythmia from the
electrocardiogram (ECG) signals to employ deep learning (DL) framework based on long …

Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management

NA Trayanova - Circulation research, 2014‏ - ahajournals.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …

[HTML][HTML] Personalized computational modeling of left atrial geometry and transmural myofiber architecture

TE Fastl, C Tobon-Gomez, A Crozier, J Whitaker… - Medical image …, 2018‏ - Elsevier
Atrial fibrillation (AF) is a supraventricular tachyarrhythmia characterized by complete
absence of coordinated atrial contraction and is associated with an increased morbidity and …

Validation and trustworthiness of multiscale models of cardiac electrophysiology

P Pathmanathan, RA Gray - Frontiers in Physiology, 2018‏ - frontiersin.org
Computational models of cardiac electrophysiology have a long history in basic science
applications and device design and evaluation, but have significant potential for clinical …