Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Insulin activated endogenous protein kinase B alpha (also known as RAC/Akt kinase)
activity 12‐fold in L6 myotubes, while after transfection into 293 cells PKBalpha was …

Lipofectamine reagents are widely accepted as “gold-standard” for the safe delivery of
exogenous DNA or RNA into cells. Despite this, a satisfactory mechanism-based …

G protein–coupled receptor kinases (GRKs) constitute a family of six mammalian
serine/threonine protein kinases that phosphorylate agonist-bound, or activated, G protein …

The spectrin-based membrane skeleton of the humble mammalian erythrocyte has provided
biologists with a set of interacting proteins with diverse roles in organization and survival of …

The plasma membrane and the underlying cortical actin cytoskeleton undergo continuous
dynamic interplay that is responsible for many essential aspects of cell physiology …

▪ Abstract Phosphoinositides [PPIs, which collectively refer to phosphorylated derivatives of
phosphatidylinositol (PI)] have a pivotal role as precursors to important second messengers …

The protein kinase encoded by the Akt proto-oncogene is activated by phospholipid binding,
membrane translocation and phosphorylation. To address the relative roles of these …

H-ras, N-ras, and K-ras are canonical ras gene family members frequently activated by point
mutation in human cancers and coding for 4 different, highly related protein isoforms (H-Ras …