Biological roles of neutrophil-derived granule proteins and cytokines
Neutrophils, the most abundant white blood cells in human circulation, entertain intense
interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such …
interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such …
[HTML][HTML] The role of CD71+ erythroid cells in the regulation of the immune response
Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …
organism against hostile invaders and to maintain tolerance to harmless microorganisms …
[HTML][HTML] Absolute quantification of transcription factors reveals principles of gene regulation in erythropoiesis
Dynamic cellular processes such as differentiation are driven by changes in the abundances
of transcription factors (TFs). However, despite years of studies, our knowledge about the …
of transcription factors (TFs). However, despite years of studies, our knowledge about the …
Proteomic analysis of young and old mouse hematopoietic stem cells and their progenitors reveals post-transcriptional regulation in stem cells
The balance of hematopoietic stem cell (HSC) self-renewal and differentiation is critical for a
healthy blood supply; imbalances underlie hematological diseases. The importance of …
healthy blood supply; imbalances underlie hematological diseases. The importance of …
Hematopoiesis during ontogenesis, adult life, and aging
A Belyavsky, N Petinati, N Drize - International Journal of Molecular …, 2021 - mdpi.com
In the bone marrow of vertebrates, two types of stem cells coexist—hematopoietic stem cells
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …
(HSCs) and mesenchymal stem cells (MSCs). Hematopoiesis only occurs when these two …
Tumor immune evasion induced by dysregulation of erythroid progenitor cells development
Simple Summary Tumor immune evasion is one of the hallmarks of tumor progression that
enables tumor growth despite the activity of the host immune system. It is mediated by …
enables tumor growth despite the activity of the host immune system. It is mediated by …
Developmental cues license megakaryocyte priming in murine hematopoietic stem cells
The fetal-to-adult switch in hematopoietic stem cell (HSC) behavior is characterized by
alterations in lineage output and entry into deep quiescence. Here we identify the …
alterations in lineage output and entry into deep quiescence. Here we identify the …
Linking benzene, in utero carcinogenicity and fetal hematopoietic stem cell niches: a mechanistic review
Previous research reported that prolonged benzene exposure during in utero fetal
development causes greater fetal abnormalities than in adult-stage exposure. This …
development causes greater fetal abnormalities than in adult-stage exposure. This …
New molecular insights into immune cell development
During development innate lymphoid cells and specialized lymphocyte subsets colonize
peripheral tissues, where they contribute to organogenesis and later constitute the first line …
peripheral tissues, where they contribute to organogenesis and later constitute the first line …
[HTML][HTML] Dynamic regulation of innate lymphoid cell development during ontogeny
T Wu, S Chen, X Zhu, J Ma, M Luo, Y Wang, Y Tian… - Mucosal …, 2024 - Elsevier
The helper-like ILC contains various functional subsets, such as ILC1, ILC2, ILC3 and LTi
cells, mediating the immune responses against viruses, parasites, and extracellular bacteria …
cells, mediating the immune responses against viruses, parasites, and extracellular bacteria …