RNA helicases are highly conserved proteins that use nucleoside triphosphates to bind or
remodel RNA, RNA–protein complexes or both. RNA helicases are classified into the DEAD …

Fundamental differences exist between males and females, encompassing anatomy,
physiology, behaviour, and genetics. Such differences undoubtedly play a part in the well …

De novo germline mutations in the RNA helicase DDX3X account for 1%–3% of
unexplained intellectual disability (ID) cases in females and are associated with autism …

Summary DEAD-Box Helicase 3 X-Linked (DDX3X) is frequently mutated in the Wingless
(WNT) and Sonic hedghog (SHH) subtypes of medulloblastoma—the commonest malignant …

Members of a paralogous gene family in which variation in one gene is known to cause
disease are eight times more likely to also be associated with human disease. Recent …

Mutations in the RNA helicase DDX3X, implicated in various cancers and
neurodevelopmental disorders, often impair RNA unwinding and translation. However, the …

De novo variants in DDX 3X account for 1–3% of unexplained intellectual disability (ID)
cases and are amongst the most common causes of ID especially in females. Forty‐seven …

Background Intellectual disability (ID) is a common condition with a population prevalence
frequency of 1–3% and an enrichment for males, driven in part by the contribution of mutant …

DEAD-box helicases are global regulators of liquid-liquid phase separation (LLPS), a
process that assembles membraneless organelles inside cells. An outstanding member of …

DDX3X (Xp11. 4) encodes a DEAD‐box RNA helicase that escapes X chromosome
inactivation. Pathogenic variants in DDX3X have been shown to cause X‐linked intellectual …