R-loops as cellular regulators and genomic threats
During transcription, the nascent RNA strand can base pair with its template DNA, displacing
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
the non-template strand as ssDNA and forming a structure called an R-loop. R-loops are …
[HTML][HTML] R loops: from physiological to pathological roles
DNA-RNA hybrids play a physiological role in cellular processes, but often, they represent
non-scheduled co-transcriptional structures with a negative impact on transcription …
non-scheduled co-transcriptional structures with a negative impact on transcription …
R-ChIP using inactive RNase H reveals dynamic coupling of R-loops with transcriptional pausing at gene promoters
SF3B1 mutation and ATM deletion codrive leukemogenesis via centromeric R-loop dysregulation
RNA splicing factor SF3B1 is recurrently mutated in various cancers, particularly in
hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and …
hematologic malignancies. We previously reported that coexpression of Sf3b1 mutation and …
Thermostability, tunability, and tenacity of RNA as rubbery anionic polymeric materials in nanotechnology and nanomedicine—specific cancer targeting with …
RNA nanotechnology is the bottom-up self-assembly of nanometer-scale architectures,
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
resembling LEGOs, composed mainly of RNA. The ideal building material should be (1) …
[HTML][HTML] HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
HOTTIP lncRNA is highly expressed in acute myeloid leukemia (AML) driven by MLL
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …
rearrangements or NPM1 mutations to mediate HOXA topologically associated domain …
TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage
M Giannini, A Bayona-Feliu, D Sproviero… - PLoS …, 2020 - journals.plos.org
TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural
resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes …
resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes …
[HTML][HTML] R-loops: formation, function, and relevance to cell stress
DF Allison, GG Wang - Cell stress, 2019 - ncbi.nlm.nih.gov
Exposure of genomic, single-stranded DNA (ssDNA) during transcription and replication
creates opportunities for the formation of inappropriate secondary structures. Cells manage …
creates opportunities for the formation of inappropriate secondary structures. Cells manage …
Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor
K Wang, H Wang, C Li, Z Yin, R **ao, Q Li, Y **ang… - Science …, 2021 - science.org
An R loop is a unique triple-stranded structure that participates in multiple key biological
processes and is relevant to human diseases. Accurate and comprehensive R loop profiling …
processes and is relevant to human diseases. Accurate and comprehensive R loop profiling …