Glucose regulation, cognition, and brain MRI in type 2 diabetes: a systematic review

SLC Geijselaers, SJS Sep, CDA Stehouwer… - The Lancet Diabetes & …, 2015 - thelancet.com
Type 2 diabetes is associated with cognitive dysfunction and structural brain changes.
Abnormalities in glucose regulation are involved in several complications related to type 2 …

Dementia risk and prevention by targeting modifiable vascular risk factors

S Tariq, PA Barber - Journal of neurochemistry, 2018 - Wiley Online Library
The incidence of dementia is expected to double in the next 20 years and will contribute to
heavy social and economic burden. Dementia is caused by neuronal loss that leads to brain …

Acute glucose fluctuation impacts microglial activity, leading to inflammatory activation or self-degradation

CF Hsieh, CK Liu, CT Lee, LE Yu, JY Wang - Scientific reports, 2019 - nature.com
Diabetes mellitus is associated with an increased risk of Alzheimer's dementia and cognitive
decline. The cause of neurodegeneration in chronic diabetic patients remains unclear …

Glucose peaks and the risk of dementia and 20-year cognitive decline

AM Rawlings, AR Sharrett, TH Mosley… - Diabetes …, 2017 - Am Diabetes Assoc
OBJECTIVE Hemoglobin A1c (HbA1c), a measure of average blood glucose level, is
associated with the risk of dementia and cognitive impairment. However, the role of glycemic …

Postural control and gait performance in the diabetic peripheral neuropathy: a systematic review

A Mustapa, M Justine, N Mohd Mustafah… - BioMed research …, 2016 - Wiley Online Library
Purpose. The aim of this paper is to review the published studies on the characteristics of
impairments in the postural control and gait performance in diabetic peripheral neuropathy …

Molecular mechanisms of glucose fluctuations on diabetic complications

ZY Zhang, LF Miao, LL Qian, N Wang, MM Qi… - Frontiers in …, 2019 - frontiersin.org
Accumulating evidence indicates the occurrence and development of diabetic complications
relates to not only constant high plasma glucose, but also glucose fluctuations which affect …

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

FJ Alfaro, A Gavrieli, P Saade-Lemus, VA Lioutas… - Metabolism, 2018 - Elsevier
Metabolic syndrome is a cluster of cardiovascular risk factors defined by the presence of
abdominal obesity, glucose intolerance, hypertension and/or dyslipidemia. It is a major …

[HTML][HTML] Association between type 2 diabetes mellitus and brain atrophy: a meta-analysis

T Zhang, M Shaw, N Cherbuin - Diabetes & metabolism …, 2022 - synapse.koreamed.org
Background Type 2 diabetes mellitus (T2DM) is known to be associated with cognitive
decline and brain structural changes. This study systematically reviews and estimates …

Reduced brain gray matter volume in patients with first-episode major depressive disorder: a quantitative meta-analysis

R Zheng, Y Zhang, Z Yang, S Han, J Cheng - Frontiers in psychiatry, 2021 - frontiersin.org
Background: The findings of many neuroimaging studies in patients with first-episode major
depressive disorder (MDD), and even those of previous meta-analysis, are divergent. To …

[HTML][HTML] Utility of different glycemic control metrics for optimizing management of diabetes

KD Kohnert, P Heinke, L Vogt… - World journal of …, 2015 - ncbi.nlm.nih.gov
The benchmark for assessing quality of long-term glycemic control and adjustment of
therapy is currently glycated hemoglobin (HbA1c). Despite its importance as an indicator for …