Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

The genomes of virtually all organisms contain repetitive sequences that are generated by
the activity of transposable elements (transposons). Transposons are mobile genetic …

Abstract The Human Silencing Hub (HUSH) complex is necessary for epigenetic repression
of LINE-1 elements. We show that HUSH-depletion in human cell lines and primary …

Retrotransposons are genomic DNA sequences that copy themselves to new genomic
locations via RNA intermediates; LINE-1 is the only active and autonomous retrotransposon …

In eukaryotes, repetitive DNA sequences are transcriptionally silenced through histone H3
lysine 9 trimethylation (H3K9me3). Loss of silencing of the repeat elements leads to genome …

Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …

Approximately 45% of the human genome is composed of transposable elements (TEs).
Expression of these elements is tightly regulated during normal development. TEs may be …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …

Mice harbor∼ 2800 intact copies of the retrotransposon Long Interspersed Element 1 (L1).
The in vivo retrotransposition capacity of an L1 copy is defined by both its sequence integrity …