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Context-specific regulation and function of mRNA alternative polyadenylation
Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …
Uncovering the impacts of alternative splicing on the proteome with current omics techniques
The high‐throughput sequencing of cellular RNAs has underscored a broad effect of isoform
diversification through alternative splicing on the transcriptome. Moreover, the differential …
diversification through alternative splicing on the transcriptome. Moreover, the differential …
[HTML][HTML] Sites of transcription initiation drive mRNA isoform selection
The generation of distinct messenger RNA isoforms through alternative RNA processing
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
modulates the expression and function of genes, often in a cell-type-specific manner. Here …
Ultra-accurate microbial amplicon sequencing with synthetic long reads
Background Out of the many pathogenic bacterial species that are known, only a fraction are
readily identifiable directly from a complex microbial community using standard next …
readily identifiable directly from a complex microbial community using standard next …
Fourth report on chicken genes and chromosomes 2022
The chicken continues to hold its position as a leading model organism within many areas of
research, as well as being a major source of protein for human consumption. The First …
research, as well as being a major source of protein for human consumption. The First …
Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons
Although mRNAs are localized in the processes of excitatory neurons, it is still unclear
whether interneurons also localize a large population of mRNAs. In addition, the variability …
whether interneurons also localize a large population of mRNAs. In addition, the variability …
Linking transport and translation of mRNAs with endosomes and mitochondria
K Müntjes, SK Devan, AS Reichert, M Feldbrügge - EMBO reports, 2021 - embopress.org
In eukaryotic cells, proteins are targeted to their final subcellular locations with precise
timing. A key underlying mechanism is the active transport of cognate mRNAs, which in …
timing. A key underlying mechanism is the active transport of cognate mRNAs, which in …
Cochlear transcript diversity and its role in auditory functions implied by an otoferlin short isoform
Isoforms of a gene may contribute to diverse biological functions. In the cochlea, the
repertoire of alternative isoforms remains unexplored. We integrated single-cell short-read …
repertoire of alternative isoforms remains unexplored. We integrated single-cell short-read …
A multi-omics view of neuronal subcellular protein synthesis
While it has long been known that protein synthesis is necessary for long-term memory in
the brain, the logistics of neuronal protein synthesis is complicated by the extensive …
the brain, the logistics of neuronal protein synthesis is complicated by the extensive …
Targeted proteoform map** uncovers specific Neurexin-3 variants required for dendritic inhibition
The diversification of cell adhesion molecules by alternative splicing is proposed to underlie
molecular codes for neuronal wiring. Transcriptomic approaches mapped detailed cell-type …
molecular codes for neuronal wiring. Transcriptomic approaches mapped detailed cell-type …