Neural mechanisms and psychology of psychedelic ego dissolution
Neuroimaging studies of psychedelics have advanced our understanding of hierarchical
brain organization and the mechanisms underlying their subjective and therapeutic effects …
brain organization and the mechanisms underlying their subjective and therapeutic effects …
Neurophysiological signatures of cortical micro-architecture
Systematic spatial variation in micro-architecture is observed across the cortex. These micro-
architectural gradients are reflected in neural activity, which can be captured by …
architectural gradients are reflected in neural activity, which can be captured by …
Pattern breaking: a complex systems approach to psychedelic medicine
Recent research has demonstrated the potential of psychedelic therapy for mental health
care. However, the psychological experience underlying its therapeutic effects remains …
care. However, the psychological experience underlying its therapeutic effects remains …
Human electromagnetic and haemodynamic networks systematically converge in unimodal cortex and diverge in transmodal cortex
Whole-brain neural communication is typically estimated from statistical associations among
electromagnetic or haemodynamic time-series. The relationship between functional network …
electromagnetic or haemodynamic time-series. The relationship between functional network …
As without, so within: how the brain's temporo-spatial alignment to the environment shapes consciousness
Consciousness is constituted by a structure that includes contents as foreground and the
environment as background. This structural relation between the experiential foreground …
environment as background. This structural relation between the experiential foreground …
Integrated world modeling theory expanded: Implications for the future of consciousness
A Safron - Frontiers in Computational Neuroscience, 2022 - frontiersin.org
Integrated world modeling theory (IWMT) is a synthetic theory of consciousness that uses the
free energy principle and active inference (FEP-AI) framework to combine insights from …
free energy principle and active inference (FEP-AI) framework to combine insights from …
Computational neurosciences and quantitative systems pharmacology: a powerful combination for supporting drug development in neurodegenerative diseases
H Geerts, S Bergeler, WW Lytton… - … of Pharmacokinetics and …, 2024 - Springer
Successful clinical development of new therapeutic interventions is notoriously difficult,
especially in neurodegenerative diseases, where predictive biomarkers are scarce and …
especially in neurodegenerative diseases, where predictive biomarkers are scarce and …
On the varieties of conscious experiences: altered beliefs under psychedelics (ALBUS)
A Safron - 2020 - osf.io
How is it that psychedelics so profoundly impact brain and mind? According to the highly
influential model of" Relaxed Beliefs Under Psychedelics"(REBUS)(Carhart-Harris & Friston …
influential model of" Relaxed Beliefs Under Psychedelics"(REBUS)(Carhart-Harris & Friston …
[HTML][HTML] The promise and pitfalls of a strength-based approach to child poverty and neurocognitive development: Implications for policy
There has been significant progress in understanding the effects of childhood poverty on
neurocognitive development. This progress has captured the attention of policymakers and …
neurocognitive development. This progress has captured the attention of policymakers and …
On Embedded Normativity an Active Inference Account of Agency Beyond Flesh
We introduce and motivate the concept of embedded normativity to account for the
externalization of social norms in the material environment through human social activity …
externalization of social norms in the material environment through human social activity …