Applications of hydrogen/deuterium exchange MS from 2012 to 2014
Hydrogen/deuterium exchange (HDX) detected by mass spectrometry (MS) is extraordinarily
useful in the study of many aspects of proteins, especially the analysis of protein …
useful in the study of many aspects of proteins, especially the analysis of protein …
From processivity to genome maintenance: the many roles of sliding clamps
Sliding clamps play a pivotal role in the process of replication by increasing the processivity
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
of the replicative polymerase. They also serve as an interacting platform for a plethora of …
An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif
D Balasubramaniam, O Schroeder, AM Russell… - Journal of Lipid …, 2022 - ASBMB
Triglycerides (TG) are required for fatty acid transport and storage and are essential for
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a …
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a …
Advanced assessment of the physicochemical characteristics of Remicade® and Inflectra® by sensitive LC/MS techniques
In this study, we demonstrate the utility of ultra-performance liquid chromatography coupled
to mass spectrometry (MS) and ion-mobility spectrometry (IMS) to characterize and compare …
to mass spectrometry (MS) and ion-mobility spectrometry (IMS) to characterize and compare …
Acetylation of PCNA sliding surface by Eco1 promotes genome stability through homologous recombination
During DNA replication, proliferating cell nuclear antigen (PCNA) adopts a ring-shaped
structure to promote processive DNA synthesis, acting as a sliding clamp for polymerases …
structure to promote processive DNA synthesis, acting as a sliding clamp for polymerases …
Beyond the mono-nucleosome
JK Dias, S D'Arcy - Biochemical Society Transactions, 2025 - portlandpress.com
Nucleosomes, the building block of chromatin, are responsible for regulating access to the
DNA sequence. This control is critical for essential cellular processes, including transcription …
DNA sequence. This control is critical for essential cellular processes, including transcription …
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases
The evolutionary role of conformational exchange in the emergence and preservation of
function within structural homologs remains elusive. While protein engineering has revealed …
function within structural homologs remains elusive. While protein engineering has revealed …
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery
S Simonsen, CK Søgaard, JG Olsen, M Otterlei… - Cellular and Molecular …, 2024 - Springer
DNA replication is a tightly coordinated event carried out by a multiprotein replication
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …
complex. An essential factor in the bacterial replication complex is the ring-shaped DNA …
Dynamics of open DNA sliding clamps
AJ Oakley - PLoS One, 2016 - journals.plos.org
A range of enzymes in DNA replication and repair bind to DNA-clamps: torus-shaped
proteins that encircle double-stranded DNA and act as mobile tethers. Clamps from viruses …
proteins that encircle double-stranded DNA and act as mobile tethers. Clamps from viruses …
Replisome assembly at bacterial chromosomes and iteron plasmids
The proper initiation and occurrence of DNA synthesis depends on the formation and
rearrangements of nucleoprotein complexes within the origin of DNA replication. In this …
rearrangements of nucleoprotein complexes within the origin of DNA replication. In this …