Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies
The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …
public health burden worldwide. The most common form of NCD is metabolic diseases …
[HTML][HTML] Novel role of the SIRT1 in endocrine and metabolic diseases
C Lu, H Zhao, Y Liu, Z Yang, H Yao, T Liu… - … Journal of Biological …, 2023 - ncbi.nlm.nih.gov
Abstract Silent information regulator 1 (SIRT1), a highly conserved NAD+-dependent
deacetylase, is a cellular regulator that has received extensive attention in recent years and …
deacetylase, is a cellular regulator that has received extensive attention in recent years and …
[HTML][HTML] Revisiting pharmacology of oxidative stress and endothelial dysfunction in cardiovascular disease: Evidence for redox-based therapies
A Daiber, S Chlopicki - Free Radical Biology and Medicine, 2020 - Elsevier
According to the latest Global Burden of Disease Study data, non-communicable diseases in
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
general and cardiovascular disease (CVD) in particular are the leading cause of premature …
Glutathione and glutaredoxin—key players in cellular redox homeostasis and signaling
YC Chai, JJ Mieyal - Antioxidants, 2023 - mdpi.com
This Special Issue of Antioxidants on Glutathione (GSH) and Glutaredoxin (Grx) was
designed to collect review articles and original research studies focused on advancing the …
designed to collect review articles and original research studies focused on advancing the …
[HTML][HTML] Glutaredoxin: Discovery, redox defense and much more
Glutaredoxin, Grx, is a small protein containing an active site cysteine pair and was
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
discovered in 1976 by Arne Holmgren. The Grx system, comprised of Grx, glutathione …
Production of adeno-associated virus vectors for in vitro and in vivo applications
Delivering and expressing a gene of interest in cells or living animals has become a pivotal
technique in biomedical research and gene therapy. Among viral delivery systems, adeno …
technique in biomedical research and gene therapy. Among viral delivery systems, adeno …
Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system xC−
Glutathione (GSH) is a critical component of the cellular redox system that combats oxidative
stress. The glutamate-cystine antiporter, system xC−, is a key player in GSH synthesis that …
stress. The glutamate-cystine antiporter, system xC−, is a key player in GSH synthesis that …
Redox Regulation via Glutaredoxin-1 and Protein S-Glutathionylation
R Matsui, B Ferran, A Oh, D Croteau… - Antioxidants & Redox …, 2020 - liebertpub.com
Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …
protein cysteines have been recognized for their critical roles in physiology and …
[HTML][HTML] Sexual dimorphism in glutathione metabolism and glutathione-dependent responses
Glutathione is the most abundant intracellular low molecular weight thiol in cells and tissues,
and plays an essential role in numerous cellular processes, including antioxidant defenses …
and plays an essential role in numerous cellular processes, including antioxidant defenses …
Mitochondrial hydrogen peroxide production by pyruvate dehydrogenase and α-ketoglutarate dehydrogenase in oxidative eustress and oxidative distress
Pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase (KGDH) are vital entry
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …
points for monosaccharides and amino acids into the Krebs cycle and thus integral for …