The tumour microenvironment (TME) highly influences the growth and spread of tumours,
thus impacting the patient's clinical outcome. In this context, the complement system plays a …

Progress at the beginning of the 21st century transformed the perception of complement
from that of a blood-based antimicrobial system to that of a global regulator of immunity and …

Mortality from breast cancer is almost exclusively a result of tumor metastasis and resistance
to therapy and therefore understanding the underlying mechanisms is an urgent challenge …

Here, using single-cell RNA sequencing, we examine the stromal compartment in murine
melanoma and draining lymph nodes (LNs) at points across tumor development, providing …

In addition to being a component of innate immunity and an ancient defense mechanism
against invading pathogens, complement activation also participates in the adaptive …

In tumour immunology, complement has traditionally been considered as an adjunctive
component that enhances the cytolytic effects of antibody-based immunotherapies, such as …

Reactivation of cytotoxic CD8+ T-cell responses has set a new direction for cancer
immunotherapy. Neutralizing antibodies targeting immune checkpoint programmed cell …

Soft tissue sarcomas (STS) are rare and diverse mesenchymal cancers with limited
treatment options. Here we undertake comprehensive proteomic profiling of tumour …

For successful translation of targeting nanomedicines from bench to bedside, it is vital to
address their most common drawbacks namely rapid clearance and off-target accumulation …

Pentraxin-3 (PTX3) belongs to the pentraxine family, innate immune regulators involved in
angiogenesis, proliferation and immune escape in cancer. Here, we evaluated PTX3 tissue …