Successful fluorine-containing herbicide agrochemicals

T Fujiwara, D O'Hagan - Journal of Fluorine Chemistry, 2014 - Elsevier
Of the herbicides licensed worldwide, currently around 25% contain at least one fluorine
atom and many contain multiple fluorines in the form of difluoro-and trifluoromethyl groups …

Structure and function of biotin-dependent carboxylases

L Tong - Cellular and Molecular Life Sciences, 2013 - Springer
Biotin-dependent carboxylases include acetyl-CoA carboxylase (ACC), propionyl-CoA
carboxylase (PCC), 3-methylcrotonyl-CoA carboxylase (MCC), geranyl-CoA carboxylase …

Metabolic engineering strategies for microbial synthesis of oleochemicals

BF Pfleger, M Gossing, J Nielsen - Metabolic engineering, 2015 - Elsevier
Microbial synthesis of oleochemicals has advanced significantly in the last decade.
Microbes have been engineered to convert renewable substrates to a wide range of …

[HTML][HTML] Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A–dependent bioproduction in rewired Pseudomonas putida

E Kozaeva, S Volkova, MRA Matos, MP Mezzina… - Metabolic …, 2021 - Elsevier
Pseudomonas putida is evolutionarily endowed with features relevant for bioproduction,
especially under harsh operating conditions. The rich metabolic versatility of this species …

Enhanced biosynthesis of fatty acids is associated with the acquisition of ciprofloxacin resistance in Edwardsiella tarda

Y Su, S Kuang, J Ye, J Tao, H Li, X Peng, B Peng - Msystems, 2021 - Am Soc Microbiol
Misuse and overuse of antibiotics drive the selection and spread of antibiotic-resistant
bacteria. Although genetic mutations have been well defined for different types of antibiotic …

New approaches to target the mycolic acid biosynthesis pathway for the development of tuberculosis therapeutics

E Jeffrey North, M Jackson… - Current pharmaceutical …, 2014 - ingentaconnect.com
Mycolic acids are the major lipid components of the unique mycobacterial cell wall
responsible for the protection of the tuberculosis bacilli from many outside threats. Mycolic …

Metabolic sensor governing bacterial virulence in Staphylococcus aureus

Y Ding, X Liu, F Chen, H Di, B Xu… - Proceedings of the …, 2014 - National Acad Sciences
An effective metabolism is essential to all living organisms, including the important human
pathogen Staphylococcus aureus. To establish successful infection, S. aureus must …

Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer

J Wei, L Tong - Nature, 2015 - nature.com
Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive
target for drug discovery against diabetes, cancer and other diseases,,,,,. Saccharomyces …

Destruction of the cell membrane and inhibition of cell phosphatidic acid biosynthesis in Staphylococcus aureus: an explanation for the antibacterial mechanism of …

D Pang, S Liao, W Wang, L Mu, E Li, W Shen, F Liu… - Food & function, 2019 - pubs.rsc.org
Morusin is a prenylated flavonoid found in mulberry that shows antimicrobial activity against
foodborne pathogens. The MIC values of morusin toward S. aureus ATCC 6538 and S …

Enhanced biosynthesis of poly(3‐hydroxybutyrate) in engineered strains of Pseudomonas putida via increased malonyl‐CoA availability

G Favoino, N Krink, T Schwanemann… - Microbial …, 2024 - Wiley Online Library
Malonyl‐coenzyme A (CoA) is a key precursor for the biosynthesis of multiple value‐added
compounds by microbial cell factories, including polyketides, carboxylic acids, biofuels, and …