The current treatment approach for systemic lupus erythematosus (SLE), as outlined in the
recommendations by international medical associations including EULAR and the ACR, is …

Systemic lupus erythematosus (SLE) is a complex disease with an insidious clinical
presentation. In up to half of the cases, SLE onset is characterized by clinical and serological …

Disease modification has become a well-established concept in several therapeutic areas;
however, no widely accepted definition of disease modification exists for SLE. We reviewed …

Background Disease activity in systemic lupus erythematosus follows three different
courses: long quiescent, relapsing remitting and persistently active. However, the patterns of …

Summary The Physician Global Assessment International Standardisation COnsensus in
Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and …

Abstract Objective The Physician Global Assessment (PGA) is a visual analogue score that
reflects the clinician's judgement of overall SLE disease activity. The aim of this systematic …

Abstract Systemic Lupus Erythematosus is a systemic autoimmune disease characterized by
a great heterogenicity in course and clinical manifestations. Although prognosis improved in …

Epigenetic dysregulation is implicated in the pathogenesis of lupus. We performed a
longitudinal analysis to assess changes in DNA methylation in lupus neutrophils over 4 …

Background Antinuclear antibodies (ANA) are major immunodiagnostic tools in systemic
lupus erythematosus (SLE); however, their clinical and pathogenic roles are not yet …

Objective The aim of this study is to compare the frequency of remission, according to
DORIS definitions, of inception patients from two European SLE cohorts, with a special focus …