Electrical activity in neurons requires a seamless functional coupling between
plasmalemmal ion channels and ion transporters. Although ion channels have been studied …

Synaptic inhibition plays a crucial role in regulating neuronal excitability, which is the
foundation of nervous system function. This inhibition is largely mediated by the …

Ionic currents and the network-driven patterns they generate differ in immature and adult
neurons: The develo** brain is not a “small adult brain.” One of the most investigated …

The develo** brain is talkative but its language is not that of the adult. Most if not all
voltage and transmitter-gated ionic currents follow a developmental sequence and network …

KCC2, best known as the neuron-specific chloride-extruder that sets the strength and
polarity of GABAergic currents during neuronal maturation, is a multifunctional molecule that …

γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the mature central
nervous system (CNS). The developmental switch of GABAergic transmission from excitation …

Subjective tinnitus is the conscious perception of sound in the absence of any acoustic
source. The literature suggests various tinnitus mechanisms, most of which invoke changes …

Highlights•Ionic plasticity of GABA signaling relies on short-term and long term changes in E
GABA.•Cl− transport and carboanhydrases play a key role in ionic plasticity and …

In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the
reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses …

As a main inhibitory neurotransmitter in the central nervous system, γ-aminobutyric acid
(GABA) activates chloride-permeable GABAa receptors (GABAa Rs) and induces chloride …