The role of the microbiota in infectious diseases
J Libertucci, VB Young - Nature microbiology, 2019 - nature.com
The human body is colonized by a diverse community of microorganisms collectively
referred to as the microbiota. Here, we describe how the human microbiota influences …
referred to as the microbiota. Here, we describe how the human microbiota influences …
Bacterial vaginosis: current diagnostic avenues and future opportunities
A healthy female genital tract harbors a microbiome dominated by lactic acid and hydrogen
peroxide producing bacteria, which provide protection against infections by maintaining a …
peroxide producing bacteria, which provide protection against infections by maintaining a …
Genital inflammation and the risk of HIV acquisition in women
Abstract Background. Women in Africa, especially young women, have very high human
immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral …
immunodeficiency virus (HIV) incidence rates that cannot be fully explained by behavioral …
The evolving facets of bacterial vaginosis: implications for HIV transmission
Bacterial vaginosis (BV) is a common yet poorly understood vaginal condition that has
become a major focus of HIV transmission and immunology research. Varied terminologies …
become a major focus of HIV transmission and immunology research. Varied terminologies …
Linking cervicovaginal immune signatures, HPV and microbiota composition in cervical carcinogenesis in non-Hispanic and Hispanic women
P Łaniewski, D Barnes, A Goulder, H Cui, DJ Roe… - Scientific reports, 2018 - nature.com
While high-risk human papillomavirus (HPV) infection is a well-established risk factor for
cervical cancer, there are likely other factors within the local microenvironment that …
cervical cancer, there are likely other factors within the local microenvironment that …
Influence of Biofilm Formation by Gardnerella vaginalis and Other Anaerobes on Bacterial Vaginosis
Bacterial vaginosis (BV) is the worldwide leading vaginal disorder among women of
reproductive age. BV is characterized by the replacement of beneficial lactobacilli and the …
reproductive age. BV is characterized by the replacement of beneficial lactobacilli and the …
Sex differences in HIV infection
EP Scully - Current HIV/AIDS Reports, 2018 - Springer
Abstract Purpose of Review This review will outline the multilevel effects of biological sex on
HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential …
HIV acquisition, pathogenesis, treatment response, and prospects for cure. Potential …
[HTML][HTML] Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and …
Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with
HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the …
HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the …
[HTML][HTML] Vaginal lactic acid elicits an anti-inflammatory response from human cervicovaginal epithelial cells and inhibits production of pro-inflammatory mediators …
AC Hearps, D Tyssen, D Srbinovski, L Bayigga… - Mucosal …, 2017 - Elsevier
Inflammation in the female reproductive tract (FRT) is associated with increased HIV
transmission. Lactobacillus spp. dominate the vaginal microbiota of many women and their …
transmission. Lactobacillus spp. dominate the vaginal microbiota of many women and their …
Distinct immune responses elicited from cervicovaginal epithelial cells by lactic acid and short chain fatty acids associated with optimal and non-optimal vaginal …
Non-optimal vaginal microbiota, as observed in bacterial vaginosis (BV), is typically
characterized by a depletion of beneficial lactobacilli and an abundance of numerous …
characterized by a depletion of beneficial lactobacilli and an abundance of numerous …