Strategies for heterologous expression, synthesis, and purification of animal venom toxins

E Rivera-de-Torre, C Rimbault, TP Jenkins… - … in bioengineering and …, 2022 - frontiersin.org
Animal venoms are complex mixtures containing peptides and proteins known as toxins,
which are responsible for the deleterious effect of envenomations. Across the animal …

[HTML][HTML] Panorama of the intracellular molecular concert orchestrated by actinoporins, pore-forming toxins from sea anemones

C Alvarez, C Soto, S Cabezas, J Alvarado-Mesén… - Toxins, 2021 - mdpi.com
Actinoporins (APs) are soluble pore-forming proteins secreted by sea anemones that
experience conformational changes originating in pores in the membranes that can lead to …

Decoupling immunomodulatory properties from lipid binding in the α-pore-forming toxin Sticholysin II

AL Rivero-Hernández, YP Hervis… - International Journal of …, 2024 - Elsevier
Sticholysin II (StII), a pore-forming toxin from the marine anemone Stichodactyla helianthus,
enhances an antigen-specific cytotoxic T lymphocyte (CTL) response when co-encapsulated …

[HTML][HTML] Development of a StIW111C-based bioresponsive pore-forming conjugate for permeabilizing the endosomal membrane

FA Escalona-Rodriguez, J La O-Bonet… - International Journal of …, 2025 - Elsevier
Gene expression manipulation is pivotal in therapeutic approaches for various diseases.
Non-viral delivery systems present a safer alternative to viral vectors, with reduced …

Unveiling Sticholysin II and plasmid DNA interaction: Implications for develo** non-viral vectors

FA Escalona-Rodriguez, Y Cruz-Leal, J La O-Bonet… - Toxicon, 2024 - Elsevier
Non-viral gene delivery systems offer significant potential for gene therapy due to their
versatility, safety, and cost advantages over viral vectors. However, their effectiveness can …

[HTML][HTML] Sea anemones, actinoporins, and cholesterol

J Palacios-Ortega, D Heras-Márquez… - International Journal of …, 2022 - mdpi.com
Spanish or Spanish-speaking scientists represent a remarkably populated group within the
scientific community studying pore-forming proteins. Some of these scientists, ourselves …

Neurotoxins and pore forming toxins in sea anemones: Potential candidates for new drug development

ZL Wang, SY Zhang, SL Hao, WX Yang - 2023 - digitum.um.es
There are two kinds of toxins in sea anemones: neurotoxins and pore forming toxins. As a
representative of the sodium channel toxin, the neurotoxin ATX II in neurotoxin mainly affects …

Impact of intrinsic and extrinsic factors on cellular sphingomyelin imaging with specific reporter proteins

T Kobayashi, N Tomishige, T Inaba, A Makino… - …, 2021 - journals.sagepub.com
Sphingomyelin (SM) is a major sphingolipid in mammalian cells. Although SM is enriched in
the outer leaflet of the cell plasma membrane, lipids are also observed in the inner leaflet of …

Recombinant production in Escherichia coli of functionally active alpha-hemolysin from the human pathogen Staphylococcus aureus

JL Diaz-Varela, V Sabia, D Heras-Marquez… - bioRxiv, 2025 - biorxiv.org
Staphylococcus aureus is a human opportunistic pathogen capable of causing multiple
infections in both humans and animals. It secretes a group of exotoxins, known as …

[PDF][PDF] Coelenterate toxins, its pharmaceutical and therapeutic effects

S SHARMA, RK UPADHYAY - Int J Curr Pharm Res, 2021 - academia.edu
Present review article emphasizes species specific coelenterate toxins, its pharmaceutical
and therapeutic effects. Most of the coelenterates inflict venom accidently by using …