Roles of mechanistic, data-driven, and hybrid modeling approaches for pharmaceutical process design and operation

MR Gaddem, J Kim, K Matsunami, Y Hayashi… - Current Opinion in …, 2024 - Elsevier
This work presents a bird's eye view depicting current trends in the pharmaceutical industry
and the role of mathematical modeling in process design and operation within the …

[KÖNYV][B] Applied parameter estimation for chemical engineers

P Englezos, N Kalogerakis - 2000 - taylorfrancis.com
This book determines adjustable parameters in mathematical models that describe steady
state or dynamic systems, presenting the most important optimization methods used for …

A new combined differential‐discrete cellular automaton approach for biofilm modeling: Application for growth in gel beads

C Picioreanu, MCM Van Loosdrecht… - Biotechnology and …, 1998 - Wiley Online Library
The theoretical basis and quantitative evaluation of a new approach for modeling biofilm
growth are presented here. Soluble components (eg, substrates) are represented in a …

Analysis of cell growth kinetics and substrate diffusion in a polymer scaffold

CJ Galban, BR Locke - Biotechnology and Bioengineering, 1999 - Wiley Online Library
The cultivation of cartilage cells (chondrocytes) in polymer scaffolds leads to implants that
may potentially be used to repair damaged joint cartilage or for reconstructive surgery. For …

[KÖNYV][B] An introduction to biomaterials

JO Hollinger, SA Guelcher - 2012 - api.taylorfrancis.com
The second edition of An Introduction to Biomaterials consists of 33 chapters that have been
conceived and organized as a practical educational road map to provide a fundamental …

Cell invasion with proliferation mechanisms motivated by time-lapse data

MJ Simpson, KA Landman, BD Hughes - Physica A: Statistical Mechanics …, 2010 - Elsevier
Cell invasion involves a population of cells which are motile and proliferative. Traditional
discrete models of proliferation involve agents depositing daughter agents on nearest …

Expansion of adipose mesenchymal stromal cells is affected by human platelet lysate and plating density

D Cholewa, T Stiehl, A Schellenberg… - Cell …, 2011 - journals.sagepub.com
The composition of mesenchymal stromal cells (MSCs) changes in the course of in vitro
culture expansion. Little is known how these cell preparations are influenced by culture …

The virtual cell—a candidate co-ordinator for 'middle-out'modelling of biological systems

DC Walker, J Southgate - Briefings in bioinformatics, 2009 - academic.oup.com
Understanding the functioning of biological systems depends on tackling complexity
spanning spatial scales from genome to organ to whole organism. The basic unit of life, the …

[KÖNYV][B] Tissue engineering and artificial organs

JD Bronzino, DR Peterson - 2016 - books.google.com
Over the last century, medicine has come out of the" black bag" and emerged as one of the
most dynamic and advanced fields of development in science and technology. Today …