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How multiscale curvature couples forces to cellular functions
Among the physicochemical cues in the cellular microenvironment that orchestrate cell
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …
processes, the different levels of curvature in the extracellular matrix and intrinsic to the …
Cell monolayers sense curvature by exploiting active mechanics and nuclear mechanoadaptation
The early development of many organisms involves the folding of cell monolayers, but this
behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of …
behaviour is difficult to reproduce in vitro; therefore, both mechanistic causes and effects of …
Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration
Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes …
folding, cellular compartmentalization and collective movements. Each of these processes …
Membrane-actin interactions in morphogenesis: Lessons learned from Drosophila cellularization
During morphogenesis, changes in the shapes of individual cells are harnessed to mold an
entire tissue. These changes in cell shapes require the coupled remodeling of the plasma …
entire tissue. These changes in cell shapes require the coupled remodeling of the plasma …
Scutoids are a geometrical solution to three-dimensional packing of epithelia
As animals develop, tissue bending contributes to shape the organs into complex three-
dimensional structures. However, the architecture and packing of curved epithelia remains …
dimensional structures. However, the architecture and packing of curved epithelia remains …
3D cell neighbour dynamics in growing pseudostratified epithelia
During morphogenesis, epithelial sheets remodel into complex geometries. How cells
dynamically organise their contact with neighbouring cells in these tightly packed tissues is …
dynamically organise their contact with neighbouring cells in these tightly packed tissues is …
Sha** organs: shared structural principles across kingdoms
Development encapsulates the morphogenesis of an organism from a single fertilized cell to
a functional adult. A critical part of development is the specification of organ forms. Beyond …
a functional adult. A critical part of development is the specification of organ forms. Beyond …
[HTML][HTML] Mechanics and self-organization in tissue development
Self-organization is an all-important feature of living systems that provides the means to
achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review …
achieve specialization and functionality at distinct spatio-temporal scales. Herein, we review …
3D shape of epithelial cells on curved substrates
Epithelia are ubiquitous tissues that display a large diversity of functions and forms, from
totally flat to highly curved. Various morphogenetic events, such as gastrulation or branching …
totally flat to highly curved. Various morphogenetic events, such as gastrulation or branching …
Local and global changes in cell density induce reorganisation of 3D packing in a proliferating epithelium
Tissue morphogenesis is intimately linked to the changes in shape and organisation of
individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes …
individual cells. In curved epithelia, cells can intercalate along their own apicobasal axes …