Hydrogels are highly water-swollen molecular networks that are ideal platforms to create
tissue mimetics owing to their vast and tunable properties. As such, hydrogels are promising …

Recent evidence clearly shows that cells respond to various physical cues in their
environments, guiding many cellular processes and tissue morphogenesis, pathology, and …

Bringing to life the fascinating structures and unique mechanics of natural and biomedical
cellular materials, this book is an expert guide to the subject for graduates and researchers …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

One of the most unique physical features of cell adhesion to external surfaces is the active
generation of mechanical force at the cell-material interface. This includes pulling forces …

Many essential cellular functions in health and disease are closely linked to the ability of
cells to respond to mechanical forces. In the context of cell adhesion to the extracellular …

Cells generate mechanical stresses via the action of myosin motors on the actin
cytoskeleton. Although the molecular origin of force generation is well understood, we …

Physical forces generated by cells drive morphologic changes during development and can
feedback to regulate cellular phenotypes. Because these phenomena typically occur within …

Mechanical stresses are ever present in the cellular environment, whether through external
forces that are applied to tissues or endogenous forces that are generated within the active …

Access to robust and information-rich human cardiac tissue models would accelerate drug-
based strategies for treating heart disease. Despite significant effort, the generation of high …