In responding to cytoplasmic nucleotide levels, ATP-sensitive potassium (KATP) channel
activity provides a unique link between cellular energetics and electrical excitability. Over …

A polymer chain of N atoms enjoys 3N-6 internal degrees of freedom, which gives rise to
infinitely many conformations. Even a simple model of N) 100 atoms where bond lengths …

The realization that experimentally observed functional motions of proteins can be predicted
by coarse-grained normal mode analysis has renewed interest in applications to structural …

ATP-sensitive potassium (KATP) channels are present in the surface and internal
membranes of cardiac, skeletal, and smooth muscle cells and provide a unique feedback …

Publisher Summary This chapter discusses the need for multivariate analysis in biophysical
studies, presents the way principal components analysis (PCA) can be implemented in the …

The beta‐cell ATP‐sensitive potassium channel is a key component of stimulus‐secretion
coupling in the pancreatic beta‐cell. The channel couples metabolism to membrane …

Potassium (K+) channels play vital roles in various physiological functions, including
regulating K+ flow in cell membranes, impacting nervous system signal transduction …

ATP-sensitive potassium (KATP) channels are composed of four pore-forming Kir6. 2
subunits and four regulatory SUR1 subunits. Binding of ATP to Kir6. 2 leads to inhibition of …

A fundamental question associated with the function of ion channels is the conformational
changes that allow for reversibly opening/occluding the pore through which the cations …

ATP‐sensitive potassium (KATP) channels couple cell metabolism to electrical activity by
regulating K+ fluxes across the plasma membrane. Channel closure is facilitated by ATP …