Advancing therapy for neuroblastoma
B Qiu, KK Matthay - Nature Reviews Clinical Oncology, 2022 - nature.com
Neuroblastomas are tumours of sympathetic origin, with a heterogeneous clinical course
ranging from localized or spontaneously regressing to widely metastatic disease …
ranging from localized or spontaneously regressing to widely metastatic disease …
Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine
The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
organ development, epithelial homeostasis, tissue regeneration, wound healing and …
Lorlatinib with or without chemotherapy in ALK-driven refractory/relapsed neuroblastoma: phase 1 trial results
KC Goldsmith, JR Park, K Kayser, J Malvar, YY Chi… - Nature medicine, 2023 - nature.com
Neuroblastomas harbor ALK aberrations clinically resistant to crizotinib yet sensitive pre-
clinically to the third-generation ALK inhibitor lorlatinib. We conducted a first-in-child study …
clinically to the third-generation ALK inhibitor lorlatinib. We conducted a first-in-child study …
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
Neuroblastoma is a tumor of the peripheral sympathetic nervous system, derived from
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
multipotent neural crest cells (NCCs). To define core regulatory circuitries (CRCs) controlling …
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations
A Villani, S Davidson, N Kanwar, WW Lo, Y Li… - Nature Cancer, 2023 - nature.com
We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …
A mechanistic classification of clinical phenotypes in neuroblastoma
S Ackermann, M Cartolano, B Hero, A Welte, Y Kahlert… - Science, 2018 - science.org
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. Its clinical course
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …
ranges from spontaneous tumor regression to fatal progression. To investigate the molecular …
Neuroblastoma—a neural crest derived embryonal malignancy
Neuroblastoma is a neural crest derived malignancy of the peripheral nervous system and is
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …
the most common and deadliest tumor of infancy. It is characterized by clinical heterogeneity …
Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1
Immunotherapy with anti-GD2 antibodies has advanced the treatment of children with high-
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
risk neuroblastoma, but nearly half of patients relapse, and little is known about mechanisms …
Super enhancers define regulatory subtypes and cell identity in neuroblastoma
Half of the children diagnosed with neuroblastoma (NB) have high-risk disease,
disproportionately contributing to overall childhood cancer-related deaths. In addition to …
disproportionately contributing to overall childhood cancer-related deaths. In addition to …
Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes
Apart from the anti-GD2 antibody, immunotherapy for neuroblastoma has had limited
success due to immune evasion mechanisms, coupled with an incomplete understanding of …
success due to immune evasion mechanisms, coupled with an incomplete understanding of …