Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Alzheimer disease (AD) is the most common form of neurodegenerative disease, estimated
to contribute 60–70% of all cases of dementia worldwide. According to the prevailing …

Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

Neurodegenerative diseases, the leading cause of morbidity and disability, are gaining
increased attention as they impose a considerable socioeconomic impact, due in part to the …

Microglia are implicated in all stages of multiple sclerosis (MS). Microglia alterations are
detected by positron emission tomography in people living with MS prior to the formation of …

The gut microbiota is a complex system, consisting of a dynamic population of
microorganisms, involved in the regulation of the host's homeostasis. A vast number of …

Aging is associated with chronic systemic inflammation, which contributes to the
development of many age-related diseases, including vascular disease. The world's …

The sustained proliferation of microglia is a key hallmark of Alzheimer's disease (AD),
accelerating its progression. Here, we aim to understand the long-term impact of the early …

Age-associated chronic inflammation is characterized by unresolved and uncontrolled
inflammation with multivariable low-grade, chronic and systemic responses that exacerbate …

Ageing is a major risk factor for develo** many neurodegenerative diseases. Cellular
senescence is a homeostatic biological process that has a key role in driving ageing. There …