In Vitro Anticancer Activity of Mucoadhesive Oral Films Loaded with Usnea barbata (L.) FH Wigg Dry Acetone Extract, with Potential Applications in Oral Squamous …

V Popovici, E Matei, GC Cozaru, L Bucur, CE Gîrd… - Antioxidants, 2022 - mdpi.com
Oral squamous cell carcinoma (OSCC) is the most frequent oral malignancy, with a high
death rate and an inadequate response to conventional chemotherapeutic drugs. Medical …

In Vitro Anticancer Activity and Oxidative Stress Biomarkers Status Determined by Usnea barbata (L.) FH Wigg. Dry Extracts

V Popovici, L Bucur, G Vochita, D Gherghel, CT Mihai… - Antioxidants, 2021 - mdpi.com
Lichens represent an important resource for common traditional medicines due to their
numerous metabolites that can exert diverse pharmacological activities including anticancer …

Usnic Acid and Usnea barbata (L.) FH Wigg. Dry Extracts Promote Apoptosis and DNA Damage in Human Blood Cells through Enhancing ROS Levels

V Popovici, E Matei, GC Cozaru, M Aschie, L Bucur… - Antioxidants, 2021 - mdpi.com
Nowadays, numerous biomedical studies performed on natural compounds and plant
extracts aim to obtain highly selective pharmacological activities without unwanted toxic …

Antioxidant and Cytotoxic Activities of Usnea barbata (L.) FH Wigg. Dry Extracts in Different Solvents

V Popovici, L Bucur, A Popescu, V Schröder… - Plants, 2021 - mdpi.com
Lichens represent a significant source of antioxidants due to numerous metabolites that can
reduce free radicals. Usnea barbata (L.) FH Wigg. has been recognized and used since …

Antioxidant, Cytotoxic, and Rheological Properties of Canola Oil Extract of Usnea barbata (L.) Weber ex FH Wigg from Călimani Mountains, Romania

V Popovici, L Bucur, CE Gîrd, D Rambu, SI Calcan… - Plants, 2022 - mdpi.com
Usnea genus (Parmeliaceae, lichenized Ascomycetes) is a potent phytomedicine, due to
phenolic secondary metabolites, with various pharmacological effects. Therefore, our study …

Cytotoxicity Analysis and In Silico Studies of Three Plant Extracts with Potential Application in Treatment of Endothelial Dysfunction

AR Ungureanu, V Popovici, C Oprean, C Danciu… - Pharmaceutics, 2023 - mdpi.com
Endothelial dysfunction is the basis of the physiopathological mechanisms of vascular
diseases. In addition to the therapeutic activity of plant extracts, cytotoxicity is significant …

UHPLC-MS Metabolomic Fingerprinting, Antioxidant, and Enzyme Inhibition Activities of Himantormia lugubris from Antarctica

C Areche, JR Parra, B Sepulveda, O García-Beltrán… - Metabolites, 2022 - mdpi.com
Himantormia lugubris is a Chilean native small lichen shrub growing in the Antarctica
region. In this study, the metabolite fingerprinting and the antioxidant and enzyme inhibitory …

Phytochemical Profile, Antioxidant and Cytotoxic Potential of Capsicum annuum (L.) Dry Hydro-Ethanolic Extract

IM Ivan, V Popovici, CL Chițescu, L Popescu… - Pharmaceutics, 2024 - mdpi.com
Capsicum annuum (L.) is one of the essential spices most frequently used in our daily
routine and has remarkable ethnobotanical and pharmacological properties. Its fruits are …

ROS-Induced DNA-Damage and Autophagy in Oral Squamous Cell Carcinoma by Usnea barbata Oil Extract—An In Vitro Study

V Popovici, AM Musuc, E Matei, O Karampelas… - International Journal of …, 2022 - mdpi.com
Oxidative stress is associated with aging, cancers, and numerous metabolic and chronic
disorders, and phenolic compounds are well known for their health-promoting role due to …

Anticancer Activity of 2-O-caffeoyl Alphitolic Acid Extracted from the Lichen, Usnea barbata 2017-KL-10

HJ Chae, GJ Kim, B Deshar, HJ Kim, MJ Shin, H Kwon… - Molecules, 2021 - mdpi.com
Colorectal cancer is one of the life-threatening ailments causing high mortality and morbidity
worldwide. Despite the innovation in medical genetics, the prognosis for metastatic …