Epilepsy is one of the most common and disabling chronic neurological disorders.
Antiseizure medications (ASMs), previously referred to as anticonvulsant or antiepileptic …

Epilepsy is a chronic neurological condition characterized by recurrent seizures that affects
millions of people worldwide. Comprehension of the complex mechanisms underlying …

Animal models for seizures and epilepsy have played a fundamental role in advancing our
understanding of basic mechanisms underlying ictogenesis and epileptogenesis and have …

Seizure severity in experimental models of epilepsy is often evaluated by means of the
Racine scale, in spite of the use of seizure induction methods that are different from those of …

Rationally designed multi-target drugs (also termed multimodal drugs, network therapeutics,
or designed multiple ligands) have emerged as an attractive drug discovery paradigm in the …

Despite the development of various new antiepileptic drugs (AEDs) since the early 1990s,
the available evidence indicates that the efficacy and tolerability of drug treatment of …

Behavioral scoring is commonly used to access seizure intensity in different seizure models.
Racine's scale, originally developed for the amygdala-kindling model, is also frequently …

The study of mechanisms of the epilepsies requires employment of animal models. Choice
of a model system depends upon several factors, including the question to be studied, the …

Control of epilepsy has primarily focused on suppressing seizure activity by antiepileptic
drugs (AEDs) after epilepsy has developed. AEDs have greatly improved the lives of people …

Generalized non-convulsive absence seizures are characterized by the occurrence of
synchronous and bilateral spike and wave discharges (SWDs) on the electroencephalogram …