We review progress towards greater mechanistic understanding and clinical translation of a
strategy to improve respiratory and non-respiratory motor function in people with …

This review explores forms of respiratory and autonomic plasticity, and associated outcome
measures, that are initiated by exposure to intermittent hypoxia. The review focuses primarily …

BACKGROUND: Studies in individuals with chronic stroke indicate high-intensity training
(HIT) focused on walking improves locomotor function, which may be due to repeated …

After spinal cord injury (SCI) respiratory complications are a leading cause of morbidity and
mortality. Acute intermittent hypoxia (AIH) triggers spinal respiratory motor plasticity in rodent …

Persons living with incomplete spinal cord injuries (SCI) often struggle to regain
independent walking due to deficits in walking mechanics. They often dedicate many weeks …

Background Parkinson's disease (PD) is a neurodegenerative disease for which no disease-
modifying therapies exist. Preclinical and clinical evidence suggest that repeated exposure …

Hypoxia represents the temporary or longer-term decrease or deprivation of oxygen in
organs, tissues, and cells after oxygen supply drops or its excessive consumption. Hypoxia …

Background Parkinson's disease (PD) is a neurodegenerative disease, for which no disease-
modifying therapies exist. Preclinical and clinical evidence suggest that hypoxia-based …

Hypotheses Moderate acute intermittent hypoxia (mAIH) elicits plasticity in both respiratory
(phrenic long-term facilitation; pLTF) and sympathetic nerve activity (sympLTF) in rats …

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