Membrane fluctuation model for understanding the effect of receptor nanoclustering on the activation of natural killer cells through biomechanical feedback
We investigated the role of ligand clustering and density in the activation of natural killer
(NK) cells. To that end, we designed reductionist arrays of nanopatterned ligands arranged …
(NK) cells. To that end, we designed reductionist arrays of nanopatterned ligands arranged …
Polymer time crystal: Mechanical activation of reversible bonds by low-amplitude high frequency excitations
Reversible supramolecular bonds play an important role in materials science and in
biological systems. The equilibrium between open and closed bonds and the association …
biological systems. The equilibrium between open and closed bonds and the association …
Coarse-grained dynamics of transiently bound fast linkers
Transient bonds between fast linkers and slower particles are widespread in physical and
biological systems. Despite their diverse structure and function, a commonality is that the …
biological systems. Despite their diverse structure and function, a commonality is that the …
The sliding motility of the bacilliform virions of Influenza A viruses
Influenza A virus (IAV) infection relies on the action of the hemagglutinin (HA) and
neuraminidase (NA) membrane proteins. The HA ligands anchor the IAV virion to the cell's …
neuraminidase (NA) membrane proteins. The HA ligands anchor the IAV virion to the cell's …
Limits on the accuracy of contact inhibition of locomotion
Cells that collide with each other repolarize away from contact, in a process called contact
inhibition of locomotion (CIL), which is necessary for correct development of the embryo. CIL …
inhibition of locomotion (CIL), which is necessary for correct development of the embryo. CIL …
Stochastic dynamics of substrate non-uniform stiffness affecting molecular adhesion in cell–substrate interface subjected to tensile loading
The mechanically heterogeneous extracellular matrix (ECM) or tissues widely exist in
biological systems and are capable of significantly regulating directional cell migration …
biological systems and are capable of significantly regulating directional cell migration …
Hop** and crawling DNA-coated colloids
Understanding the motion of particles with multivalent ligand-receptors is important for
biomedical applications and material design. Yet, even among a single design, the …
biomedical applications and material design. Yet, even among a single design, the …
Active gel model for one-dimensional cell migration coupling actin flow and adhesion dynamics
Migration of animal cells is based on the interplay between actin polymerization at the front,
adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active …
adhesion along the cell-substrate interface, and actomyosin contractility at the back. Active …
Mechanical activation of reversible bonds by low amplitude high frequencies excitations
M Heidari, T Gaichies, L Leibler… - arxiv preprint arxiv …, 2023 - arxiv.org
Reversible covalent or supramolecular bonds play an important role in materials science
and in biological systems. The equilibrium between open and closed bonds and the …
and in biological systems. The equilibrium between open and closed bonds and the …
Deciphering the role of the nanoscale clustering of activating and costimulatory antibodies on T cell activation
In a joint experimental and a modeling effort, we explored the regulation of T cell activation
and cytotoxicity by the nanoscale clustering and surface density of activating and …
and cytotoxicity by the nanoscale clustering and surface density of activating and …