Natural ageing of organisms and corresponding age-related diseases result mainly from
stem cell ageing and “inflammaging”. Mesenchymal stem cells (MSCs) exhibit very high …

Chondrocytes are the main cell type in articular cartilage. They are embedded in an
avascular, abundant, and specialized extracellular matrix (ECM). Chondrocytes are …

Extracellular matrix (ECM) stiffness is a major driver of stem cell fate. However, the
involvement of the three-dimensional (3D) genomic reorganization in response to ECM …

Breast muscle growth rate and intramuscular fat (IMF) content show apparent differences
between fast-growing broilers and slow-growing indigenous chickens. However, the …

Most of the single-nucleotide polymorphisms (SNPs) associated with insulin resistance (IR)-
relevant phenotypes by genome-wide association studies (GWASs) are located in …

Skeletal development is tightly coordinated by chondrocytes and osteoblasts, which are
derived from skeletal progenitors, and distinct cell-type gene regulatory programs underlie …

The precise roles of chromatin organization at osteoporosis risk loci remain largely elusive.
Here, we combined chromatin interaction conformation (Hi-C) profiling and self-transcribing …

Central obesity is associated with higher risk of develo** a wide range of diseases
independent of overall obesity. Genome-wide association studies (GWASs) have identified …

Military Deployment to Southwest Asia and Afghanistan and exposure to toxic airborne
particulates have been associated with an increased risk of develo** respiratory disease …

While understanding the genetic underpinnings of osteogenesis has far-reaching
implications for skeletal diseases and evolution, a comprehensive characterization of the …