Growth hormone, insulin-like growth factors, and the skeleton

A Giustina, G Mazziotti, E Canalis - Endocrine reviews, 2008 - academic.oup.com
Abstract GH and IGF-I are important regulators of bone homeostasis and are central to the
achievement of normal longitudinal bone growth and bone mass. Although GH may act …

The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling

S Theoleyre, Y Wittrant, SK Tat, Y Fortun… - Cytokine & growth factor …, 2004 - Elsevier
The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

RANK/RANKL: regulators of immune responses and bone physiology

A Leibbrandt, JM Penninger - … of the New York Academy of …, 2008 - Wiley Online Library
Bone‐related diseases, such as osteoporosis and rheumatoid arthritis, affect hundreds of
millions of people worldwide and pose a tremendous burden to health care. By deepening …

Nanoparticle effects on stress response pathways and nanoparticle–protein interactions

SJ Cameron, J Sheng, F Hosseinian… - International journal of …, 2022 - mdpi.com
Nanoparticles (NPs) are increasingly used in a wide variety of applications and products;
however, NPs may affect stress response pathways and interact with proteins in biological …

The critical interplay between bone resorbing and bone forming cells

UH Lerner, E Kindstedt… - Journal of clinical …, 2019 - Wiley Online Library
Aim In this article, the interplay between bone resorbing and bone forming cells is reviewed.
Method This review examines the comprehensive literature on the interaction between bone …

The role of insulin-like growth factor-1 in bone remodeling: A review

J Fang, X Zhang, X Chen, Z Wang, S Zheng… - International Journal of …, 2023 - Elsevier
Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in
bone cells. The abnormal expression of IGF-1 has a serious effect on bone growth …

Role of IGF‐I signaling in regulating osteoclastogenesis

Y Wang, S Nishida, HZ Elalieh, RK Long… - Journal of bone and …, 2006 - academic.oup.com
We showed that IGF‐I deficiency impaired osteoclastogenesis directly and/or indirectly by
altering the interaction between stromal/osteoblastic cells and osteoclast precursors …

The role of cathepsin K in normal bone resorption.

BR Troen - Drug news & perspectives, 2004 - europepmc.org
Cathepsin K is essential for normal bone resorption; humans lacking cathepsin K exhibit
pycnodysostosis, which is characterized by short stature and osteosclerosis. Cathepsin K …

Biology of the TRANCE axis

MC Walsh, Y Choi - Cytokine & growth factor reviews, 2003 - Elsevier
As the TNF and TNFR superfamilies have grown to more than two dozen combined
members over the past 30 years, their involvement in interactions between immune cells …

Cytokines in crevicular fluid and orthodontic tooth movement

Y Ren, A Vissink - European journal of oral sciences, 2008 - Wiley Online Library
This review aimed to evaluate studies on cytokines in the gingival crevicular fluid (GCF)
during orthodontic treatment, summarizing the regulation patterns of the most commonly …