The term “macrolide” was originally proposed by RB Woodward in 1957 as an abbreviation
of macrolactone glycoside antibiotics, a class of natural products composed of macrocyclic …

Covering: 2000 to 2006 Nonribosomal peptides and polyketides have attracted
considerable attention in basic and applied research and have given rise to a multitude of …

In a survey of microbial systems capable of generating unusual metabolite structural
variability, Streptomyces venezuelae ATCC 15439 is notable in its ability to produce two …

Polyketides are a huge family of natural products well-known for their antibiotic, antifungal,
antiparasitic, immunosuppressive, and antitumor activities. 1 Polyketides are synthesized in …

Background: Streptomyces venezuelae produces two groups of antibiotics that include the
12-membered ring macrolides methymycin and neomethymycin, and the 14-membered ring …

The Streptomyces venezuelae pikD gene from the pikromycin biosynthetic cluster was
analyzed, and its deduced product (PikD) was found to have amino acid sequence …

Polyketides and nonribosomal peptides constitute a large and diverse set of natural
products with biological activity in microbial survival and pathogenesis, as well as broad …

Biosynthesis of Fatty Acid and Polyketide Metabolites Page 1 Biosynthesis of Fatty Acid and
Polyketide Metabolites David O'Hagan Department of Chemistry, University of Durham, Science …

Modular polyketide synthases are giant multifunctional enzymes that catalyse the
condensation of small carboxylic acids such as acetate and propionate into structurally …

The plasmid-based replacement of the multifunctional protein subunits of the pikromycin
PKS in S. venezuelae by the corresponding subunits from heterologous modular PKSs …