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The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …
Myeloid-derived suppressor cells as immunosuppressive regulators and therapeutic targets in cancer
K Li, H Shi, B Zhang, X Ou, Q Ma, Y Chen… - Signal transduction and …, 2021 - nature.com
Myeloid-derived suppressor cells (MDSCs) are a heterogenic population of immature
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
myeloid cells with immunosuppressive effects, which undergo massive expansion during …
The immunological and metabolic landscape in primary and metastatic liver cancer
X Li, P Ramadori, D Pfister, M Seehawer… - Nature Reviews …, 2021 - nature.com
The liver is the sixth most common site of primary cancer in humans, and generally arises in
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by …
Advances in immunotherapy for hepatocellular carcinoma
B Sangro, P Sarobe, S Hervás-Stubbs… - Nature reviews …, 2021 - nature.com
Hepatocellular carcinoma (HCC) is a prevalent disease with a progression that is modulated
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …
by the immune system. Systemic therapy is used in the advanced stage and until 2017 …
[PDF][PDF] Emerging immunotherapy for HCC: A guide for hepatologists
HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …
From NASH to HCC: current concepts and future challenges
Caloric excess and sedentary lifestyle have led to a global epidemic of obesity and
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
metabolic syndrome. The hepatic consequence of metabolic syndrome and obesity …
[HTML][HTML] The bidirectional immune crosstalk in metabolic dysfunction-associated steatotic liver disease
K Sawada, H Chung, S Softic, ME Moreno-Fernandez… - Cell metabolism, 2023 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an unabated risk factor
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
for end-stage liver diseases with no available therapies. Dysregulated immune responses …
Neutrophils as potential therapeutic targets in hepatocellular carcinoma
The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …
[HTML][HTML] Tumor microenvironment of hepatocellular carcinoma: challenges and opportunities for new treatment options
The prevalence of liver cancer is constantly rising, with increasing incidence and mortality in
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
Europe and the USA in recent decades. Among the different subtypes of liver cancers …
Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …