Aging and diabetes mellitus are 2 well-known risk factors for cardiovascular disease (CVD).
During the past 50 years, there has been an dramatic increase in life expectancy with a …

Mitochondrial dysfunction has been implicated in the pathogenesis of insulin resistance, the
hallmark of type 2 diabetes mellitus (T2DM). However, the cause-effect relationship remains …

Altered metabolism of lipids is currently considered a hallmark characteristic of many
malignancies, including colorectal cancer (CRC). Lipids are a large group of metabolites …

A growing body of evidence highlights the close association between nutrition and human
health. Fat is an essential macronutrient, and vegetable oils, such as palm oil, are widely …

Enlarged fat cells in obese adipose tissue diminish capacity to store fat and are resistant to
the anti-lipolytic effect of insulin. Insulin resistance (IR)-associated S-nitrosylation of insulin …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Mitochondrial dysfunction and endoplasmic reticulum (ER) stress have been suggested to
play a key role in insulin resistance development. Reactive oxygen species (ROS) …

Mitochondrial dysfunction in skeletal muscle has been implicated in the development of
insulin resistance and type 2 diabetes. Considering the importance of mitochondrial …

Focus on the Warburg effect, initially descriptive of increased glycolysis in cancer cells, has
served to illuminate mitochondrial function in many other pathologies. This review explores …

Parallel to the increasing prevalence of obesity in the world, the mortality from
cardiovascular disease has also increased. Low-grade chronic inflammation in obesity …