Leishmaniasis is a parasitic disease and is categorized as a tropically neglected disease
(NTD) with no effective vaccines available. The available chemotherapeutics against …

Leishmaniasis, a disease caused by Leishmania parasites and transmitted via sandflies,
presents in two main forms: cutaneous and visceral, the latter being more severe. With 0.7 to …

The 7-quinolinyl-bearing triazole analogs were synthesized (1d–19d) and further assessed
in vitro for their inhibitory profile against α-amylase andα-glucosidase. The entire analogs …

Leishmaniasis is a parasitic disease and categorised as a neglected tropical disease (NTD).
Each year, between 70, 0000 and 1 million new cases are believed to occur. There are …

Rutaceae is a family expressed by approximately 2100 species distributed in 154 genera
widespread in tropical and temperate regions of Australasia, America, and South Africa …

Since the beginning of the XXI century, Leishmaniasis has been integrated into the World
Health Organization's list of the 20 neglected tropical diseases, being considered a public …

A novel series of 14 spiropyrrolidines bearing thiochroman-4-one/chroman-4-one, and
oxindole/acenaphthylene-1, 2-dione moieties were synthesized and characterized by …

Pathogenic bacteria, with their innate resistance to drugs, pose a constant threat to human
health and well-being and put a persistent strain on the health care system. Development of …

In accordance with WHO statistics, leishmaniasis is one of the top neglected tropical
diseases, affecting around 700 000 to one million people per year. To that end, a new series …

In this work, the SOFT. PTML tool has been used to pre-process a ChEMBL dataset of pre-
clinical assays of antileishmanial compound candidates. A comparative study of different ML …