Naphthalene, a versatile platform in medicinal chemistry: sky-high perspective
Naphthalene, a cytotoxic moiety, is an extensively explored aromatic conjugated system with
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …
applications in various pathophysiological conditions viz. anticancer, antimicrobial, anti …
An insight into medicinal attributes of dithiocarbamates: Bird's eye view
Dithiocarbamates are considered as an important motif owing to its extensive biological
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
applications in medicinal chemistry. The synthesis of this framework can easily be achieved …
Ruthenium‐Catalyzed Aminomethylation and Methylation of Phenol Derivatives Utilizing Methanol as the C1 Source
S Kim, SH Hong - Advanced Synthesis & Catalysis, 2017 - Wiley Online Library
A reaction involving ortho‐aminomethylation of phenol was developed via ruthenium‐
catalyzed dehydrogenation of methanol, an environmentally benign C1 building block …
catalyzed dehydrogenation of methanol, an environmentally benign C1 building block …
Iodine (III)-mediated, controlled di-or monoiodination of phenols
An oxidative procedure for the electrophilic iodination of phenols was developed by using
iodosylbenzene as a nontoxic iodine (III)-based oxidant and ammonium iodide as a cheap …
iodosylbenzene as a nontoxic iodine (III)-based oxidant and ammonium iodide as a cheap …
An Update on the Synthesis of Pyrrolo [1, 4] benzodiazepines
G Varvounis - Molecules, 2016 - mdpi.com
Pyrrolo [1, 4] benzodiazepines are tricyclic compounds that are considered “privileged
structures” since they possess a wide range of biological activities. The first encounter with …
structures” since they possess a wide range of biological activities. The first encounter with …
Design, synthesis and biological evaluation of imidazo [1, 5-a] pyridine–PBD conjugates as potential DNA-directed alkylating agents
A Kamal, G Ramakrishna, MJ Ramaiah… - …, 2013 - pubs.rsc.org
A series of novel imidazo [1, 5-a] pyridine–PBD conjugates were synthesized and evaluated
for their antitumor activity in breast cancer cell line (MCF-7). Interestingly, all the compounds …
for their antitumor activity in breast cancer cell line (MCF-7). Interestingly, all the compounds …
Synthesis of terphenyl benzimidazoles as tubulin polymerization inhibitors
A series of new terphenyl benzimidazoles (3a–z and 3aa–ad) were synthesized and
evaluated for their anticancer activity. All the 30 compounds have shown moderate to good …
evaluated for their anticancer activity. All the 30 compounds have shown moderate to good …
Dithiocarbamate/piperazine bridged pyrrolobenzodiazepines as DNA-minor groove binders: Synthesis, DNA-binding affinity and cytotoxic activity
A new series of C8-linked dithiocarbamate/piperazine bridged pyrrolo [2, 1-c][1, 4]
benzodiazepine conjugates (5a–c, 6a, b) have been synthesized and evaluated for their …
benzodiazepine conjugates (5a–c, 6a, b) have been synthesized and evaluated for their …
Synthetic modified pyrrolo [1, 4] benzodiazepine molecules demonstrate selective anticancer activity by targeting the human ligase 1 enzyme: An in silico and in vitro …
Abstract Human DNA ligase1 (hLig1) is the major replicative enzyme in proliferating
mammalian cells that join Okazaki fragments of the lagging strand during DNA replication …
mammalian cells that join Okazaki fragments of the lagging strand during DNA replication …
Natural product-inspired rational design, synthesis and biological evaluation of 2, 3-dihydropyrano [2, 3-f] chromen-4 (8H)-one based hybrids as potential …
P Sakthivel, A Ilangovan, MP Kaushik - European Journal of Medicinal …, 2016 - Elsevier
Synthesis of novel pyranochromanone amide hybrids, by combining pyranochromanone
pharmacophore and privileged scaffolds such as 2-amino-1, 3, 4-thiadiaole/2 …
pharmacophore and privileged scaffolds such as 2-amino-1, 3, 4-thiadiaole/2 …