Nitric oxide (NO) is a gaseous lipophilic free radical cellular messenger generated by three
distinct isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and …

Nitric oxide is a highly versatile heterodiatomic molecule that effects a variety of actions in
the vasculture. Originally identified as a principal determination of vascular tone, nitric oxide …

Background—HMG-CoA Reductase Inhibitors (statins) reduce cardiac event rates in
patients with stable coronary heart disease. Withdrawal of chronic statin treatment during …

Nitric oxide (NO) is a short-lived gaseous signaling molecule. In blood vessels, it is
synthesized in a dynamic fashion by endothelial nitric oxide synthase (eNOS) and …

Nitric oxide synthases (NOS) are the enzymes responsible for nitric oxide (NO) generation.
NO is a reactive oxygen species as well as a reactive nitrogen species. It is a free radical …

Vascular endothelium plays a key role in the local regulation of vascular tone and vascular
architecture by release of vasodilator and vasoconstrictor substances, as well as factors with …

Large-scale trials established that statin administration in hypercholesterolaemic individuals
and patients with coronary heart disease (CHD) significantly reduces the risk of vascular …

The present review considers the potential pleiotropic effects of statins and the evidence
indicative of the “real world” benefit from these effects in patients with cardiovascular …

Long-term treatment in rats with l-NAME, an isoform-non-specific inhibitor of nitric oxide
synthase (NOS), leads to fibrosis of the heart and kidney, suggesting that nitric oxide (NO) …

Gene therapy aims to intervene in a disease process by transfer and expression of specific
genes in a target tissue or organ. Cardiovascular gene therapy in humans remains in its …