1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …

Comparative genomics shows that a substantial fraction of the genes in sequenced
genomes encodes 'conserved hypothetical'proteins, ie those that are found in organisms …

Functional links between proteins can often be inferred from genomic associations between
the genes that encode them: groups of genes that are required for the same function tend to …

A large part of mammalian proteomes is represented by hypothetical proteins (HP), ie
proteins predicted from nucleic acid sequences only and protein sequences with unknown …

Proteins are the most essential and versatile macromolecules of life, and the knowledge of
their functions is a crucial link in the development of new drugs, better crops, and even the …

Rapid advances in high-throughout genome sequencing technologies have resulted in
millions of protein-encoding gene sequences with no functional characterization. Automated …

The PEDANT genome database (http://pedant. gsf. de) provides exhaustive automatic
analysis of genomic sequences by a large variety of established bioinformatics tools through …

The progress in genome sequencing has led to a rapid accumulation in GenBank
submissions of uncharacterized 'hypothetical'genes. These genes, which have not been …

Gene order in prokaryotes is conserved to a much lesser extent than protein sequences.
Only some operons, primarily those that encode physically interacting proteins, are …

SNAPPI-DB, a high performance database of Structures, iNterfaces and Alignments of
Protein–Protein Interactions, and its associated Java Application Programming Interface …