African animal trypanosomiasis: A systematic review on prevalence, risk factors and drug resistance in sub-Saharan Africa

I Okello, E Mafie, G Eastwood… - Journal of medical …, 2022 - academic.oup.com
African animal trypanosomiasis (AAT) a parasitic disease of livestock in sub-Saharan Africa
causing tremendous loses. Sub-Saharan continental estimation of mean prevalence in both …

Antimicrobial peptides (AMPs): potential therapeutic strategy against trypanosomiases?

M Rojas-Pirela, U Kemmerling, W Quiñones… - Biomolecules, 2023 - mdpi.com
Trypanosomiases are a group of tropical diseases that have devastating health and socio-
economic effects worldwide. In humans, these diseases are caused by the pathogenic …

[HTML][HTML] Landscapes of protein posttranslational modifications of African Trypanosoma parasites

N Zhang, N Jiang, K Zhang, L Zheng, D Zhang, X Sang… - Iscience, 2020 - cell.com
Proteins of all living cells undergo a myriad of post-translational modifications (PTMs) that
are critical to multifarious life processes. In this study, we describe the first comprehensive …

[HTML][HTML] Antiparasitic potential of asteraceae plants: A comprehensive review on therapeutic and mechanistic aspects for biocompatible drug discovery

C Kamaraj, C Ragavendran, RCS Kumar, A Ali… - Phytomedicine …, 2022 - Elsevier
Background Medicinal herbs are used to cure parasitic protozoan diseases. Protozoan
parasites continue difficult to treat, but diverse extracts from both terrestrial and aquatic …

To the skin and beyond: The immune response to African trypanosomes as they enter and exit the vertebrate host

OA Alfituri, JF Quintana, A MacLeod, P Garside… - Frontiers in …, 2020 - frontiersin.org
African trypanosomes are single-celled extracellular protozoan parasites transmitted by
tsetse fly vectors across sub-Saharan Africa, causing serious disease in both humans and …

[HTML][HTML] Tackling slee** sickness: Current and promising therapeutics and treatment strategies

M Jamabo, M Mahlalela, AL Edkins… - International Journal of …, 2023 - mdpi.com
Human African trypanosomiasis is a neglected tropical disease caused by the extracellular
protozoan parasite Trypanosoma brucei, and targeted for eradication by 2030. The COVID …

Malate dehydrogenase in parasitic protozoans: roles in metabolism and potential therapeutic applications

AL Springer, S Agrawal, EP Chang - Essays in Biochemistry, 2024 - portlandpress.com
The role of malate dehydrogenase (MDH) in the metabolism of various medically significant
protozoan parasites is reviewed. MDH is an NADH-dependent oxidoreductase that …

Genetic diversity of trypanosome species in tsetse flies (Glossina spp.) in Nigeria

JS Weber, SCH Ngomtcho, SS Shaida, GD Chechet… - Parasites & …, 2019 - Springer
Background Trypanosomes cause disease in humans and livestock in sub-Saharan Africa
and rely on tsetse flies as their main insect vector. Nigeria is the most populous country in …

Metabolites from trypanosome-infected cattle as sensitive biomarkers for animal trypanosomosis

MN Getahun, J Ngiela, JMO Makwatta… - Frontiers in …, 2022 - frontiersin.org
Trypanosomes are important global livestock and human pathogens of public health
importance. Elucidating the chemical mechanisms of trypanosome-relevant host interactions …

[HTML][HTML] Trypanosomiasis: An emerging disease in Alpine swift (Tachymarptis melba) nestlings in Switzerland?

P Cigler, G Moré, P Bize, CM Meier, CF Frey… - International Journal for …, 2024 - Elsevier
Alpine swifts (Tachymarptis melba) are sub-Saharan migratory birds, which, in Switzerland,
nest in colonies that have been continuously monitored for over 40 years. In the summer of …