A perspective on oligonucleotide therapy: Approaches to patient customization
It is estimated that the human genome encodes 15% of proteins that are considered to be
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …
disease-modifying. Only 2% of these proteins possess a druggable site that the approved …
LNA (locked nucleic acid): high-affinity targeting of complementary RNA and DNA
B Vester, J Wengel - Biochemistry, 2004 - ACS Publications
Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …
nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar …
RNA‐PROTACs: degraders of RNA‐binding proteins
Defects in the functions of RNA binding proteins (RBPs) are at the origin of many diseases;
however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new …
however, targeting RBPs with conventional drugs has proven difficult. PROTACs are a new …
LNA: a versatile tool for therapeutics and genomics
M Petersen, J Wengel - Trends in biotechnology, 2003 - cell.com
Locked nucleic acid (LNA) is a nucleic acid analogue that displays unprecedented
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …
hybridization affinity towards complementary DNA and RNA. Structural studies have shown …
Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality
J Elmén, H Thonberg, K Ljungberg… - Nucleic acids …, 2005 - academic.oup.com
Therapeutic application of the recently discovered small interfering RNA (siRNA) gene
silencing phenomenon will be dependent on improvements in molecule bio-stability …
silencing phenomenon will be dependent on improvements in molecule bio-stability …
Aptamers and the next generation of diagnostic reagents
Antibodies have been extensively used as capture and detection reagents in diagnostic
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
applications of proteomics‐based technologies. Proteomic assays need high sensitivity and …
Application of locked nucleic acids to improve aptamer in vivo stability and targeting function
KS Schmidt, S Borkowski, J Kurreck… - Nucleic acids …, 2004 - academic.oup.com
Aptamers are powerful candidates for molecular imaging applications due to a number of
attractive features, including rapid blood clearance and tumor penetration. We carried out …
attractive features, including rapid blood clearance and tumor penetration. We carried out …
[HTML][HTML] Harnessing reactive oxygen/nitrogen species and inflammation: Nanodrugs for liver injury
Overall, 12% of the global population (800 million) suffers from liver disease, which causes 2
million deaths every year. Liver injury involving characteristic reactive oxygen/nitrogen …
million deaths every year. Liver injury involving characteristic reactive oxygen/nitrogen …
Enhanced allele‐specific PCR discrimination in SNP genoty** using 3′ locked nucleic acid (LNA) primers
D Latorra, K Campbell, A Wolter, JM Hurley - Human mutation, 2003 - Wiley Online Library
The specificity and reliability of locked nucleic acid (LNA) substitution at the 3′ position of
allele‐specific PCR (AS‐PCR) primers for SNP detection was investigated in direct …
allele‐specific PCR (AS‐PCR) primers for SNP detection was investigated in direct …
A direct comparison of anti-microRNA oligonucleotide potency
KA Lennox, MA Behlke - Pharmaceutical research, 2010 - Springer
Purpose Cataloguing endogenous miRNA targets by inhibiting miRNA function is
fundamental to understanding the biological importance of each miRNA in gene regulatory …
fundamental to understanding the biological importance of each miRNA in gene regulatory …