Recombinant protein expression in Escherichia coli: advances and challenges

GL Rosano, EA Ceccarelli - Frontiers in microbiology, 2014 - frontiersin.org
Escherichia coli is one of the organisms of choice for the production of recombinant proteins.
Its use as a cell factory is well-established and it has become the most popular expression …

Recombinant protein expression in Escherichia coli

F Baneyx - Current opinion in biotechnology, 1999 - Elsevier
Escherichia coli is one of the most widely used hosts for the production of heterologous
proteins and its genetics are far better characterized than those of any other microorganism …

Recombinant protein folding and misfolding in Escherichia coli

F Baneyx, M Mujacic - Nature biotechnology, 2004 - nature.com
The past 20 years have seen enormous progress in the understanding of the mechanisms
used by the enteric bacterium Escherichia coli to promote protein folding, support protein …

Strategies for optimization of heterologous protein expression in E. coli: Roadblocks and reinforcements

J Kaur, A Kumar, J Kaur - International journal of biological …, 2018 - Elsevier
E. coli is most preferred system used for the production of recombinant proteins in bacteria
and the availability of improved genetic tools/methods are making it more valuable than …

Soluble expression of recombinant proteins in the cytoplasm of Escherichia coli

HP Sørensen, KK Mortensen - Microbial cell factories, 2005 - Springer
Pure, soluble and functional proteins are of high demand in modern biotechnology. Natural
protein sources rarely meet the requirements for quantity, ease of isolation or price and …

Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements

CJ Huang, H Lin, X Yang - Journal of Industrial Microbiology and …, 2012 - academic.oup.com
Nearly 30% of currently approved recombinant therapeutic proteins are produced in
Escherichia coli. Due to its well-characterized genetics, rapid growth and high-yield …

[PDF][PDF] Protein stability: a crystallographer's perspective

MC Deller, L Kong, B Rupp - Acta Crystallographica Section F …, 2016 - journals.iucr.org
Protein stability is a topic of major interest for the biotechnology, pharmaceutical and food
industries, in addition to being a daily consideration for academic researchers studying …

Production of biopharmaceuticals in E. coli: current scenario and future perspectives

MN Baeshen, AM Al-He**, RS Bora… - … of microbiology and …, 2015 - koreascience.kr
Escherichia coli is the most preferred microorganism to express heterologous proteins for
therapeutic use, as around 30% of the approved therapeutic proteins are currently being …

Production of active eukaryotic proteins through bacterial expression systems: a review of the existing biotechnology strategies

S Sahdev, SK Khattar, KS Saini - Molecular and cellular biochemistry, 2008 - Springer
Among the various expression systems employed for the over-production of proteins,
bacteria still remains the favorite choice of a Protein Biochemist. However, even today, due …

Biotechnological uses of enzymes from psychrophiles

R Cavicchioli, T Charlton, H Ertan… - Microbial …, 2011 - Wiley Online Library
The bulk of the Earth's biosphere is cold (eg 90% of the ocean's waters are≤ 5° C),
sustaining a broad diversity of microbial life. The permanently cold environments vary from …