Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to
eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy …

Human development requires intricate cell specification and communication pathways that
allow an embryo to generate and appropriately connect more than 200 different cell types …

Biological membranes are complex and dynamic assemblies of lipids and proteins.
Poikilothermic organisms including bacteria, fungi, reptiles, and fish do not control their body …

The posttranslational modification with ubiquitin, a process referred to as ubiquitylation,
controls almost every process in cells. Ubiquitin can be attached to substrate proteins as a …

Aroma compounds provide attractiveness and variety to alcoholic beverages. We discuss
the molecular biology of a major subset of beer aroma volatiles, fruity and floral compounds …

Between the 1960s and 1980s, most life scientists focused their attention on studies of
nucleic acids and the translation of the coded information. Protein degradation was a …

▪ Abstract The conjugation of ubiquitin to other cellular proteins regulates a broad range of
eukaryotic cell functions. The high efficiency and exquisite selectivity of ubiquitination …

The proteasome is an intricate molecular machine, which serves to degrade proteins
following their conjugation to ubiquitin. Substrates dock onto the proteasome at its 19 …

To maintain protein homeostasis, AAA+ proteolytic machines degrade damaged and
unneeded proteins in bacteria, archaea and eukaryotes. This process involves the ATP …

▪ Abstract The cellular stress response is a universal mechanism of extraordinary
physiological/pathophysiological significance. It represents a defense reaction of cells to …