Early detection and monitoring are critical to the diagnosis and management of glaucoma, a
progressive optic neuropathy that causes irreversible blindness. Optical coherence …

There are many unanswered questions on the relation of intraocular pressure to glaucoma
development and progression. IOP itself cannot be distilled to a single, unifying value …

The development of the visual system involves the coordination of spatial and temporal
events to specify the organization of varied cell types, including the elongation of axons from …

Reduced blood flow and impaired neurovascular coupling are recognized features of
glaucoma, the leading cause of irreversible blindness worldwide, but the mechanisms …

Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in
irreversible vision loss due to the mammalian central nervous system's limited regenerative …

Transient receptor potential (TRP) channels are a widely expressed family of 28
evolutionarily conserved cationic ion channels that operate as primary detectors of chemical …

The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …

Glaucoma causes loss of vision through degeneration of the retinal ganglion cell (RGC)
projection to the brain. The disease is characterized by sensitivity to intraocular pressure …

Glutamate neurotransmission and metabolism are finely modulated by the retinal network,
where the efficient processing of visual information is shaped by the differential distribution …