Absorption of ultraviolet (UV) radiation can trigger a variety of photophysical and
photochemical reactions in nucleic acids. In the prebiotic era, on the surface of the early …

Coded ribosomal peptide synthesis could not have evolved unless its sequence and amino
acid–specific aminoacylated tRNA substrates already existed. We therefore wondered …

Why life encodes specific proteinogenic amino acids remains an unsolved problem, but a
non-enzymatic synthesis that recapitulates biology's universal strategy of stepwise N-to-C …

The first ribozymes are thought to have emerged at a time when RNA replication proceeded
via nonenzymatic template copying processes. However, functional RNAs have stable …

Due to the non-degradable and persistent nature of metal ions in the environment, they are
released into water bodies, where they accumulate in fish. In order to assess pollution in …

Demonstrating RNA catalysis within prebiotically relevant models of primordial cells
(protocells) remains a challenge in origins of life research. Fatty acid vesicles encapsulating …

Ribozymes, widely found in prokaryotes and eukaryotes, target nucleic acids and can be
engineered as biotechnical tools or for gene regulation or immune therapy. Among them …

Manganese( ii ) promotes prebiotically plausible non-enzymatic RNA ligation reactions -
Chemical Communications (RSC Publishing) DOI:10.1039/D4CC01086H Royal Society of …

Mechanisms underlying how the genetic code was generated by Darwinian selection have
remained elusive since the code was cracked in 1965. Here, I propose a hypothesis on the …

Coded ribosomal peptide synthesis could not have evolved unless its sequence and amino
acid specific aminoacylated tRNA substrates already existed. We therefore wondered …